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Exogenous LEA proteins expression enhances cold tolerance in mammalian cells by reducing oxidative stress.
Sci Rep
January 2025
Department of Veterinary Medicine, University of Teramo, Via Renato Balzarini 1, 64100, Teramo, Italy.
Understanding the molecular mechanisms that confer cold resistance in mammalian cells might be relevant for advancing medical applications. This study aimed to exploit the protective function of Late Embryogenesis Abundant (LEA) proteins, known to provide resistance to low temperatures in extremophiles and plants, by their exogenous expression in mammalian cells, and compare their effects with the well characterized antioxidant, vitamin E.Remarkably, the expression of LEA proteins in mammalian cells exerted cold-protective effect similar to Vitamin E.
View Article and Find Full Text PDFExogenous selenium enhances cadmium stress tolerance by improving physiological characteristics of Artemisia argyi seedlings.
Sci Rep
January 2025
College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
The contamination of Chinese medicinal materials with cadmium (Cd) is a pressing global issue that poses significant risks to human health. The beneficial effects of selenium (Se) have been established in improving plant growth and reducing Cd accumulation in plant under Cd stress. This study employed soil cultivation experiments to investigate the remediation effects of exogenous Se (0, 0.
View Article and Find Full Text PDFAptazyme-directed A-to-I RNA editing.
Methods Enzymol
January 2025
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Science, Chengdu, P.R. China. Electronic address:
As a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity. Compared to CRISPR-based gene editing techniques, RNA editing events are temporary, which can reduce the risk of long-term unintended side effects, making off-target edits less concerning than DNA-targeting methods.
View Article and Find Full Text PDFSulfate-reducing bacteria block cadmium and lead uptake in rice by regulating sulfur metabolism.
J Appl Microbiol
January 2025
College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Aim: This study was dedicated to investigating the role of sulfur metabolic processes in sulfate-reducing bacteria in plant resistance to heavy metal contamination.
Methods And Results: We constructed sulfate-reducing bacterial communities based on the functional properties of sulfate-reducing strains, and then screened out the most effective sulfate-reducing bacterial community SYN1, that prevented Cd and Pb uptake in rice through hydroponic experiment. This community lowered Cd levels in the roots and upper roots by 36.
Starch retrogradation in starch-based foods: Mechanisms, influencing factors, and mitigation strategies.
Int J Biol Macromol
January 2025
Institute of Spice and Beverage Research, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China; Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Hainan 571533, China; Sanya Research Academy, Chinese Academy of Tropical Agriculture Science, Sanya 572019, China. Electronic address:
Starch-based foods are the most common foods in the daily diets. However, starch-based foods are prone to starch retrogradation, resulting in texture hardening, taste deterioration and nutrient loss. This paper reviewed the mechanisms and the influencing factors of starch retrogradation in starch-based foods, and the strategies to mitigate it.
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