The authors study the usefulness of the measurement of the negative area of P in V1 (Morris' index) in patients with acute myocardial infarction. The study was carried out prospectively in 70 patients, 31 of them having a Swan-Ganz catheter inserted permitting simultaneous hemodynamic and electrocardiographic measurements. No overall correlation was found between pulmonary capillary pressure (PCP) and Morris' index (Mlx), but a correlation existed in the subgroup of patients that showed evident variations of Mlx values during the study. On admission a relationship between PCP and Mlx was evident in 68% of the cases, without statistical significance. No PCP-Mlx correlation was found in the patients in whom the Mlx was always normal or abnormal during the study, nor in those with a prior history of arterial hypertension or left heart failure. An intraatrial conduction defect was found in 13% of the cases, no PCP-Mlx correlation being present in those. The fact that the PCP-Mlx correlation is best in patients with changing Mlx values in successive measurements that in patients with a prior history of hypertension or left ventricular failure suggests that Mlx values may vary with changes of left atrial pressure. The measurement of the Mlx to estimate left atrial pressure has little value in patients with conditions that may cause left atrial enlargement and intraatrial conduction defects.
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November 2024
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33511, Egypt.
In this study, bupivacaine (BUP) and meloxicam (MLX) were simultaneously assayed in their co-formulated ampoules without interference using four affordable, sensitive, and eco-friendly spectrophotometric methods. The assay of MLX at 359.3 nm over the concentration range of 1.
View Article and Find Full Text PDFVet Anim Sci
September 2024
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Given that oxidative stress (OS) occurs as one of the complications of general anesthesia and surgical procedures, practicing the best and safest anesthesia regimen can have a significant share in various surgeries. So, this study compared the effects of non-steroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen (KTP) and meloxicam (MLX) on OS through the glutathione pathway after the ketamine-xylazine (K-X) anesthesia and ulcer induction in rats to suggest post-operative regimens with promising analgesic and anti-inflammatory effects. 80 healthy adult male Wistar rats, were examined in this study.
View Article and Find Full Text PDFPharmaceutics
July 2024
Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad 10071, Iraq.
The article aimed to formulate an MLX binary ethosome hydrogel for topical delivery to escalate MLX solubility, facilitate dermal permeation, avoid systemic adverse events, and compare the permeation flux and efficacy with the classical type. MLX ethosomes were prepared using the hot method according to the Box-Behnken experimental design. The formulation was implemented according to 16 design formulas with four center points.
View Article and Find Full Text PDFInt J Mol Sci
October 2023
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Wool fiber is a textile material that is highly valued based on its diameter, which is crucial in determining its economic value. To analyze the molecular mechanisms regulating wool fiber diameter, we used a Data-independent acquisition-based quantitative proteomics approach to analyze the skin proteome of Alpine Merino sheep with four fiber diameter ranges. From three contrasts of defined groups, we identified 275, 229, and 190 differentially expressed proteins (DEPs).
View Article and Find Full Text PDFGels
August 2023
Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 60-780 Poznan, Poland.
The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline cellulose was used as the disintegrant. Meloxicam (MLX), the drug used to treat rheumatic diseases for children and adults, was proposed as the active pharmaceutical ingredient (API).
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