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Simultaneous sensitive detection and imaging of dual microRNAs through DNA tetrahedral scaffold-corbelled autonomous-motion molecular machine.
Talanta
January 2025
School of Life Science, Jiangsu Normal University, Xuzhou, 221116, China.
Sensitive and accurate detection and imaging of different microRNAs (miRNAs) in cancer cells hold great promise for early disease diagnosis. Herein, a DNA tetrahedral scaffold (DTS)-corbelled autonomous-motion (AM) molecular machine based fluorescent sensing platform was designed for simultaneous detection of two types of miRNAs (miRNA-21 and miRNA-155) in HeLa cells. Locking-strand-silenced DNAzymes (P:L duplex) were firstly grafted at the loop of target-analogue-embedded double-stem hairpin substrates (TDHS) of DTS, making the sensor in a "signal off" state due to the closely distance between modified fluorophores (FAM and Cy5) with the corresponding quenchers (BHQ1 and BHQ2).
View Article and Find Full Text PDFIn Situ Ag-Seeded Lamellar TiC Nanosheets: An Electroactive Interface for Noninvasive Diagnosis of Oral Carcinoma via Salivary TNF-α Sensing.
ACS Appl Bio Mater
January 2025
Department of Chemical Engineering, Indian Institute of Technology Tirupati, Tirupati, Andhra Pradesh 517619, India.
In the fast-paced quest for early cancer detection, noninvasive screening techniques have emerged as game-changers, offering simple and accessible avenues for precession diagnostics. In line with this, our study highlights the potential of silver nanoparticle-decorated titanium carbide MXene nanosheets (TiC_AgNPs) as an electroactive interface for the noninvasive diagnosis of oral carcinoma based on the prevalence of the salivary biomarker, tumor necrosis factor-α (TNF-α). An in situ reduction was utilized to synthesize the TiC_AgNPs nanohybrid, wherein TiC acts as the reducing agent, and the resulting nanohybrid was subjected to various characterization techniques to examine the optical, structural, and morphological attributes.
View Article and Find Full Text PDFSilk Fibroin Hydrogel for Pulse Waveform Precise and Continuous Perception.
Adv Healthc Mater
December 2024
School of Perfume and Aroma Technology, Shanghai Institute of Technology Shanghai, Shanghai, 201418, China.
Precise and continuous monitoring of blood pressure and cardiac function is of great importance for early diagnosis and timely treatment of cardiovascular diseases. The common tests rely on on-site diagnosis and bulky equipments, hindering early diagnosis. The emerging hydrogels have gained considerable attention in skin bioelectronics by virtue of the similarities to biological tissues and versatility in mechanical, electrical, and biofunctional engineering.
View Article and Find Full Text PDFA mitochondria-targeted nitric oxide probe with large Stokes shift for real-time imaging and evaluation of inflammatory bowel disease in situ.
Anal Chim Acta
December 2024
Center of Excellence for Environmental Safety and Biological Effects, Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry, Beijing University of Technology, 100124, Beijing, PR China. Electronic address:
Article Synopsis
- Inflammatory bowel disease (IBD) is linked to abnormal nitric oxide production by the iNOS enzyme, making accurate diagnosis crucial for monitoring the condition.
- A new fluorescent probe, Cy-OMe, was developed to target mitochondria, providing a "turn-on" signal for nitric oxide detection, greatly improving imaging and sensitivity.
- Cy-OMe shows promise for non-invasive diagnosis of intestinal inflammation by accurately measuring nitric oxide levels in real-time within affected areas.
Vitamin D serum levels in patients with systemic sclerosis and very early systemic sclerosis (VEDOSS).
J Scleroderma Relat Disord
August 2024
Department of Advanced Medical and Surgical Sciences, "Luigi Vanvitelli" University of Campania, Naples, Italy.
Introduction: Vitamin D may be capable of interfering with the pathophysiological pathways involved in systemic sclerosis, by virtue of its well-known immunomodulatory effects. In this study, we aimed at evaluating the differences and the correlations between vitamin D levels in systemic sclerosis patients versus patients with very early systemic sclerosis.
Methods: One hundred twenty-six patients (80 definite systemic sclerosis and 46 very early systemic sclerosis) were included in this case control study.
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