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Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study.
J Mol Histol
October 2024
Human Anatomy and Embryology Department, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Adriamycin is a cytotoxic anthracycline antibiotic used to treat a wide variety of cancers. This study was made to detect the possible prophylactic effects of combining garlic and resveratrol in preventing adriamycin-induced pulmonary cytotoxicity. This study was conducted on a total number of 60 adult male albino rats.
View Article and Find Full Text PDFProtective Effects of PACAP in a Rat Model of Diabetic Neuropathy.
Int J Mol Sci
October 2021
Department of Anatomy, MTA-PTE PACAP Research Team, Centre for Neuroscience, Szentagothai Research Centre, University of Pecs Medical School, Szigeti ut 12, H-7624 Pecs, Hungary.
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with a widespread occurrence and diverse effects. PACAP has well-documented neuro- and cytoprotective effects, proven in numerous studies. Among others, PACAP is protective in models of diabetes-associated diseases, such as diabetic nephropathy and retinopathy.
View Article and Find Full Text PDFSalidroside-pretreated mesenchymal stem cells contribute to neuroprotection in cerebral ischemic injury in vitro and in vivo.
J Mol Histol
December 2021
College of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, People's Republic of China.
Mesenchymal stem cells (MSCs) are considered a promising tool for treating cerebral ischemic injury. However, their poor survival after transplantation limits their therapeutic effect and applications. Salidroside has been reported to exert potent cytoprotective and neuroprotective effects.
View Article and Find Full Text PDFAltered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP, in type 1 diabetes.
Diabetologia
October 2021
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Aims/hypothesis: Normal cellular prion protein (PrP) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a glycophosphatidylinositol anchor. Although PrP is expressed by a wide range of tissues throughout the body, the complete repertoire of its functions has not been fully determined. The misfolded pathogenic isoform PrP (the scrapie form of PrP) is a causative agent of neurodegenerative prion diseases.
View Article and Find Full Text PDFAssessment of the cytoprotective effect of the homeopathic compound Canova® on African green monkey kidney (VERO) cell line exposed to the drug dipyrone sodium.
J Toxicol Environ Health A
September 2021
Laboratory of Human Cytogenetic, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém-Pará, Brazil.
Dipyrone or metamizole is one of the most frequently used analgesic worldwide. Despite its widespread use, this drug may exert genotoxic and cytotoxic effects on lymphocytes. Therefore, studies with therapeutic agents that may provide protection against these effects are important.
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