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Probiotic KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic study.
Front Cell Infect Microbiol
August 2024
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Introduction: Bacterial urinary tract infections (UTI) are among the most common infectious diseases worldwide. The rise of multidrug-resistant (MDR) uropathogenic (UPEC) UTI cases is a significant threat to healthcare systems. Several probiotic bacteria have been proposed as an alternative to combat MDR UTI.
View Article and Find Full Text PDFThe role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens.
Vet Res
January 2024
Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493, Greifswald, Insel Riems, Germany.
Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2 is encoded in a second open frame in the polymerase segment PB1 and its sequence varies with the host of origin. While mammalian isolates predominantly carry truncated forms, avian isolates typically express full-length PB1-F2.
View Article and Find Full Text PDFAdenovirus type D and type E infection in broiler chickens: the effect on CD4 and CD8 T cell response, cytokines expression and their immunopathology.
Br Poult Sci
December 2023
Department of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
1. A total of 150-day-old chicks were divided into three groups of 50 birds (G1-G3); G1 and G2 were orally inoculated at 1-day old with 0.5 ml of 10 TCID50/ml FAdV-D serotype 2 (MT386509.
View Article and Find Full Text PDFOvalbumin-specific CD4 and CD8 T cells contribute to different susceptibility for Theiler's murine encephalomyelitis virus persistence.
Front Immunol
June 2023
Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Article Synopsis
- Theiler's murine encephalomyelitis virus (TMEV) leads to TMEV-induced demyelinating disease in susceptible mice, serving as a model for chronic progressive multiple sclerosis in humans.
- OT-mice, bred on a TMEV-resistant background, have a deficiency in specific T cell populations, making them more vulnerable to TMEV infections.
- Infected OT-I mice showed severe motor dysfunction and high virus loads, while OT-II mice exhibited milder disease and partial recovery, indicating different immune responses to TMEV.
Comparative Analysis of Different Inbred Chicken Lines Highlights How a Hereditary Inflammatory State Affects Susceptibility to Avian Influenza Virus.
Viruses
February 2023
Division of Immunology, The Roslin Institute & R(D)SVS, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK.
Evidence suggests that susceptibility to avian influenza A virus in chickens is influenced by host genetics, but the mechanisms are poorly understood. A previous study demonstrated that inbred line 0 chickens are more resistant to low-pathogenicity avian influenza (LPAI) infection than line CB.12 birds based on viral shedding, but the resistance was not associated with higher AIV-specific IFNγ responses or antibody titres.
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