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[Paternal inheritance mediated by epigenetic changes in sperms].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Epigenetics is the link between the genome and environment, which can respond to physiological (such as age) or environmental factors (such as diet, stress, and pollution) and induce changes in epigenetic modifications (such as DNA methylation, non-coding RNA, and histone modifications). It can also serve as cellular memory transmitted from generation to generation. Sperm is highly responsive to such environmental changes and has unique epigenetic profiles.
View Article and Find Full Text PDFDNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos.
Nat Commun
January 2025
Friedrich Miescher Institute for Biomedical Research, Fabrikstrasse 24, 4056, Basel, Switzerland.
In the germ line and during early embryogenesis, DNA methylation (DNAme) undergoes global erasure and re-establishment to support germ cell and embryonic development. While DNAme acquisition during male germ cell development is essential for setting genomic DNA methylation imprints, other intergenerational roles for paternal DNAme in defining embryonic chromatin are unknown. Through conditional gene deletion of the de novo DNA methyltransferases Dnmt3a and/or Dnmt3b, we observe that DNMT3A primarily safeguards against DNA hypomethylation in undifferentiated spermatogonia, while DNMT3B catalyzes de novo DNAme during spermatogonial differentiation.
View Article and Find Full Text PDFB Chromosome Transcriptional Inactivation in the Spermatogenesis of the Grasshopper .
Genes (Basel)
November 2024
Departamento de Biología, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Background/objectives: We analyzed the relationship between synapsis, recombination, and transcription during the spermatogenesis of the grasshopper carrying B chromosomes (type B1).
Methods: The progression of synapsis was interpreted according to the dynamics of the cohesin subunit SMC3 axes. DNA double-strand breaks were revealed by RAD51 immunolabeling, while transcriptional activity was determined by the presence of RNA polymerase II phosphorylated at serine 2 (pRNApol II) immunolabeling.
The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation.
Hum Reprod Update
December 2024
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Background: Varicocele is an abnormal dilation and torsion of the pampiniform venous plexus in the scrotum due to venous reflux, primarily affecting the left side. It affects 15% of men and is a prevalent contributor to male infertility. Varicocele is a complex disorder influenced by genetic, epigenetic, and environmental factors.
View Article and Find Full Text PDFLARP7 is required for sex chromosome silencing during meiosis in mice.
PLoS One
December 2024
Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Article Synopsis
- Meiotic sex chromosome inactivation (MSCI) is crucial for the proper development of sperm in mammals.
- The study highlights that La Ribonucleoprotein 7 (LARP7) is key for MSCI, promoting germ cell proliferation but displaying different activation stages throughout development.
- In mice lacking LARP7, spermatogenesis halts at the spermatocyte stage, with ongoing transcription of sex chromosome genes, indicating a failure in MSCI and abnormal epigenetic modifications in the XY body.
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