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Novel Pharmacologic Treatments of Female Sexual Dysfunction.
Clin Obstet Gynecol
March 2025
Department of Psychiatry & Neurobehavioral Sciences.
This review evaluates pharmacologic treatments for female sexual dysfunction (FSD), focusing on hypoactive sexual desire disorder (HSDD). We provide clinically relevant applications for Food and Drug Administration (FDA)-approved medications (flibanserin and bremelanotide) and investigational therapies (Lorexys and testosterone combinations). Detailed study outcomes, safety profiles, and clinical strategies guide clinicians in appropriate diagnosis, patient selection, expectation setting, side effect management, and patient education, improving treatment outcomes and patient satisfaction.
View Article and Find Full Text PDFTwin testosterone transfer hypothesis and the second-to-fourth digit ratio in females of same-sex and opposite-sex twin pairs: An exploratory study.
Physiol Rep
January 2025
Department of Epidemiology, Biostatistics and Disease Control, University for Development Studies, Tamale, Ghana.
The twin testosterone transfer (TTT) hypothesis posits that females with male co-twins (opposite-sex, OS) might develop male-typical traits due to higher prenatal testosterone exposure. This study explored whether females of OS have lower 2D:4D digit ratios and higher testosterone levels compared to females of same-sex (SS) twin pairs. Conducted in Tamale from January to December 2022, the study included 40 participants aged 18-27 years: 10 males of OS, 10 females of OS, and 20 females of SS twin pairs.
View Article and Find Full Text PDFEffects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis.
J Ovarian Res
January 2025
LongHua Hospital Shanghai University of Traditional Chinese Medicine, No.725 Wanping South Road, Xuhui District, Shanghai, 200032, China.
Objective: To systematically evaluate the effectiveness of non-pharmacological interventions (NPIs), including electroacupuncture, exercise, diet, and lifestyle changes, in reducing androgen levels in women with polycystic ovary syndrome (PCOS) through a systematic review and network meta-analysis.
Methods: Comprehensive searches were conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang up to June 2024. Randomized controlled trials (RCTs) comparing NPIs with other NPIs or placebo treatments in adult women with PCOS were included.
[A CASE OF TESTICULAR TUMOR UNDER CONSIDERATION FOR PARTIAL ORCHIECTOMY THROUGH RAPID INTRAOPERATIVE DIAGNOSIS].
Nihon Hinyokika Gakkai Zasshi
January 2025
Department of Urology and Renal Transplantation, Yokohama City University Medical Center.
A 35-year-old man visited a local doctor for continuing analysis of his infertility. Semen analysis revealed azoospermia while an ultrasonography detected a right testicular tumor with a diameter of 10 mm. A blood test was negative for tumor markers.
View Article and Find Full Text PDFMuscle parameters in men and oxidative stress markers.
J Physiol Anthropol
January 2025
University of Wrocław, Wrocław, Poland.
Background: The oxidative handicap hypothesis posits that testosterone-dependent traits, such as muscle mass and strength, may be costly to develop due to testosterone's pro-oxidative properties, leading to increased oxidative stress. This hypothesis suggests that only individuals with superior biological conditions can afford these costs. This study examines the oxidative handicap hypothesis, exploring the relationship between muscle mass or handgrip strength and oxidative stress markers in men.
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