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Carcinosarcoma of the breast: Facing the challenge of a rare nosologic entity.
World J Clin Cases
January 2025
Department of Surgery, National and Kapodistrian University of Athens, Athens 11527, Greece.
Carcinosarcoma (CS), also known as metaplastic breast carcinoma with mesenchymal differentiation, is one of the five distinct subtypes of metaplastic breast cancer. It is considered as a mixed, biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition zone. Although cellular origin of this neoplasm remains controversial, most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic differentiation.
View Article and Find Full Text PDFCould Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?
Diagnostics (Basel)
November 2024
Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
View Article and Find Full Text PDF[Mechanisms of prolonged symptoms following acute COVID-19: Some pathophysiological pathways].
Rev Mal Respir
November 2024
Service des maladies infectieuses et tropicales, CHU d'Angers, 4, rue Larrey, 49100 Angers, France. Electronic address:
Introduction: Following the Omicron wave in early 2022, an estimated 60-70% of the French population was infected with the SARS-CoV-2 virus. One out of ten infected subjects could have persistent symptoms three months after infection, representing a public health challenge.
Current State Of Knowledge: The persistent symptoms may be secondary to diverse entities with distinct mechanisms.
Characterization of Bipolar Disorder I and II: Clinical Features, Comorbidities, and Pharmacological Pattern.
Alpha Psychiatry
August 2024
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy.
Article Synopsis
- The study aims to compare sociodemographic factors, clinical features, comorbidities, and treatment patterns between patients with bipolar disorder type I (BD I) and type II (BD II).
- A total of 680 patients were assessed; findings revealed that BD I patients tend to be younger males who are single and unemployed, whereas BD II patients have a higher prevalence of suicide attempts and psychiatric comorbidities, along with more frequent alcohol use.
- The results highlight distinct profiles for BD I and II, emphasizing the need for tailored therapeutic strategies and improved clinical classifications to enhance treatment outcomes.
Immune response to viscerotropic : a comprehensive review.
Front Immunol
October 2024
Department of Health Sciences, University of Florence, Florence, Italy.
and infections are associated with a broad clinical spectrum, ranging from asymptomatic cases to visceral leishmaniasis (VL) with high mortality rates. Clinical manifestations such as post-kala-azar dermal leishmaniasis (PKDL) and visceral leishmaniasis-associated hemophagocytic lymphohistiocytosis-mimic (VL-associated HLH-mimic) further contribute to the diversity of clinical manifestations. These clinical variations are intricately influenced by the complex interplay between the host's immune response and the parasite's escape mechanisms.
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