Quantitative structure-activity studies. 2nd Communication: De novo calculations on antilipemic activity of 4-(4-chlorobenzyl)phenoxyacetic acid esters.

Quantitative structure-activity studies are carried out on antilipemic activity of 4-(4-chlorobenzyl)phenoxyacetic acid esters (1). Fujita-Ban group contributions are calculated for a variety of substituents. It is observed that when R1 is pyrid-3-ylmethyl, it has maximum contribution to activity and minimum toxic effects expressed in terms of liver growth. It is further noted that alkyl group substitution at position alpha to the carboxylic group leads to higher toxicities.