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Monitoring the Influence of Hand, Foot, and Mouth Disease: New Guidelines on Patient Care during the 2011-2012 Multiwaves and Multivariant Outbreak in Hai Phong City, Vietnam.
Pathogens
September 2024
CIRAD, UMR 17, Intertryp, TA-A17/G, Campus International de Baillarguet, CEDEX 5, 34398 Montpellier, France.
Article Synopsis
- * Official guidelines were issued during the epidemic to better manage the crisis, which helped alter patient patterns and reduce severity and time to admission for affected individuals.
- * The outbreak featured three distinct waves of HFMD, primarily caused by Enterovirus A71 and Coxsackievirus A16, with infection routes linked to local trade and transportation along rivers and secondary roads, affecting mainly children aged 0.5 to 3 years.
Modeling the Dynamic of Multiwave Diseases: The Model of Hand, Foot and Mouth Disease.
Viruses
July 2024
Cirad, UMR 17, Intertryp, TA-A17/G, Campus International de Baillarguet, CEDEX 5, 34398 Montpellier, France.
An HFMD outbreak spread over the city of Hải Phòng from summer 2011 to autumn 2012. This epidemic was chosen because it was the very first HFMD epidemic in North Vietnam, eliminating thus interferences with previous outbreaks. This epidemic displayed three separate waves.
View Article and Find Full Text PDFFoot-and-Mouth Disease Virus Serotype O Exhibits Phenomenal Genetic Lineage Diversity in India during 2018-2022.
Viruses
July 2023
ICAR-National Institute on Foot and Mouth Disease, International Centre for FMD, Arugul, Bhubaneswar 752050, India.
In India, widespread foot-and-mouth disease (FMD) outbreaks occurred in 2021. The objective of this study was to identify genetic lineages and evaluate the antigenic relationships of FMD virus (FMDV) isolates gathered from outbreaks reported between 2019 and 2022. Our study shows that the lineages O/ME-SA/Ind2001e and the O/ME-SA/Cluster-2018 were both responsible for the FMD outbreaks on an epidemic scale during 2021.
View Article and Find Full Text PDFThermostable negative-marker foot-and-mouth disease virus serotype O induces protective immunity in guinea pigs.
Appl Microbiol Biotechnol
February 2023
FMD Vaccine Research Laboratory, ICAR-Indian Veterinary Research Institute, Hebbal, Bengaluru, 560 024, India.
Foot-and-mouth disease (FMD) is a contagious viral disease of high economic importance, caused by FMD virus (FMDV), a positive-sense single-stranded RNA virus, affecting cloven-hoofed animals. Preventive vaccination using inactivated virus is in practice to control the disease in many endemic countries. While the vaccination induces antibodies mainly to structural proteins, the presence of antibodies to the non-structural proteins (NSP) is suggestive of infection, a criterion for differentiation of infected from vaccinated animals (DIVA).
View Article and Find Full Text PDFA single amino acid substitution in the VP2 protein of Indian foot-and-mouth disease virus serotype O vaccine strain confers thermostability and protective immunity in cattle.
Transbound Emerg Dis
November 2022
ICAR-Indian Veterinary Research Institute, Bengaluru, India.
Foot-and-mouth disease (FMD) is a significant threat to animal health globally. Prophylactic vaccination using inactivated FMD virus (FMDV) antigen is being practised for the control in endemic countries. A major limitation of the current vaccine is its susceptibility to high environmental temperature causing loss of immunogenicity, thus necessitating the cold chain for maintenance of its efficacy.
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