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A traumatic bone cyst is a pseudocyst, lacking an epithelial lining, and may contain fluid, connective tissue, or both. The pathogenesis of traumatic bone cyst remains unknown, but the most accepted explanation is the traumatic hemorrhagic theory. A traumatic bone cyst typically presents as a radiolucent lesion.
View Article and Find Full Text PDFCase Report: Coexistence of Rosai-Dorfman disease and B-cell acute lymphoblastic leukemia in an adolescent.
Front Pediatr
February 2025
Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rosai-Dorfman disease (RDD) is an unusual, non-malignant proliferative disorder involving non-Langerhans cell histiocytes, characterized by a wide range of clinical presentations and distinctive atypical morphological patterns. The concurrent manifestation of acute lymphoblastic leukemia (ALL) alongside RDD is exceptionally rare. Here, we present the case of a 14-year-old male patient diagnosed with ALL who, during the consolidation phase of chemotherapy, developed multifocal bone, dural, and liver lesions, as confirmed through CT and MRI imaging.
View Article and Find Full Text PDFClinical spectrum and uncommon features of McCune-Albright syndrome in children: a cohort study from a National Referral Center.
Front Endocrinol (Lausanne)
March 2025
Hospices Civils de Lyon, Hôpital Femme Mère Enfant, Service d'Endocrinologie Pédiatrique et Pédiatrie Générale, Bron, France.
Introduction: McCune-Albright syndrome (MAS) is a rare disease caused by somatic gain-of-function variants in the gene that lead to constitutive activation of the G protein alpha subunit (Gsα). Pathologic consequences can involve several tissues. Fibrous dysplasia (FD), café-au-lait skin macules and hyperfunctioning endocrinopathies are classic manifestations.
View Article and Find Full Text PDFEsophageal Siderosis: An Unusual Complication of Oral Iron Therapy.
ACG Case Rep J
March 2025
Division of Gastroenterology and Hepatology, University of Virginia Medical Center, Charlottesville, VA.
Iron is the most common nutritional deficiency encountered in the United States, with over 15% of Americans using some form of daily oral iron supplementation. Although commonly associated with minor gastrointestinal side effects, severe gastrointestinal complications are rare. Direct cytotoxic mucosal damage and subsequent ulcer formation have rarely been reported.
View Article and Find Full Text PDFProtothecosis in Dogs: A Narrative Review.
J Vet Intern Med
March 2025
Centre for Veterinary Education, Sydney School of Veterinary Science, The University of Sydney, Sydney, Australia.
Protothecosis is a rare and unusual disease that affects both humans and animals, including dogs. The causative agents are unicellular, achlorophyllous, "yeast-like" microalgae of the genus Prototheca (Trebouxiophyceae, Chlorophyta). Although usually saprophytic, Prototheca may, under conditions of immunologic compromise, become pathogenic and even lethal to the host.
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