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Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome.
Cephalalgia
March 2016
Department of Neurology, Asahi General Hospital, Japan
Background: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headaches with reversible cerebral vasoconstriction, and often precipitated by the postpartum state and vasoactive medications. We describe a case of a patient with RCVS induced by amezinium metilsulfate, a sympathomimetic drug, in whom magnetic resonance angiography (MRA) initially revealed diffusely dilated cerebral arteries.
Case Description: A 34-year-old woman was prescribed amezinium metilsulfate for hypotension.
[Cathecholamine].
Nihon Rinsho
June 2004
Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.
Successful treatment of retrograde ejaculation with amezinium.
Arch Androl
December 2003
Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
The effect of amezinium, a new type of antihypotensive agent, on retrograde ejaculation was evaluated in 3 patients with retrograde ejaculation. The patients received 10 mg amezinium orally once a day. All patients achieved antegrade ejaculation.
View Article and Find Full Text PDFAmezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy.
Clin Auton Res
February 2003
Department of Neurology, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan.
In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %, p < 0.05). Amezinium metilsulfate most probably stimulates both alpha1B-receptors in the vascular wall and alpha1A/D-receptors in the proximal urethra.
View Article and Find Full Text PDFDetermination of amezinium in plasma by RP HPLC and its application to bioequivalence studies.
Acta Pol Pharm
April 2002
Department of Inorganic & Analytical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
A modified method is described for the determination of 4-amino-6-methoxy-l-phenylpyridazinium methyl sulfate (amezinium metisulfate) in plasma and in the dosage form. The method involves a sample preparation using SPE and liquid-liquid extraction and subsequent determination by high performance liquid chromatography. Retention time for amezinium was 3.
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