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Nuclear calcium signaling in D1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine.
Biol Psychiatry
January 2025
Institute of Biology Paris-Seine, laboratory Neuroscience Paris-Seine, CNRS, INSERM, Sorbonne Université, UPMC Université Paris 06 F-75005, Paris, France. Electronic address:
Background: The persistence of cocaine-evoked adaptations relies on gene regulations within the reward circuit, especially in the ventral striatum (i.e., nucleus accumbens (NAc)).
View Article and Find Full Text PDFElemental partitioning, morpho-physiological effects, genotoxicity, and health risk assessment associated with tomato (Solanum lycopersicum L.) grown in soil contaminated with mining tailings.
Environ Res
January 2025
Doctorado en Ciencias Ambientales, Centro de Ciencias de Desarrollo Regional, Universidad Autónoma de Guerrero. Privada de Laurel 13, Col. El Roble, 39640, Acapulco, Guerrero, México; Facultad de Ciencias Agropecuarias y Ambientales, Unidad Tuxpan, Universidad Autónoma de Guerrero. Carretera Iguala-Tuxpan, km 2.5, Iguala de la Independencia, Guerrero, México; Facultad de Ciencias Agropecuarias, Universidad Autónoma del Estado de Morelos. Avenida Universidad 1001, 62210, Cuernavaca, Morelos, México; Laboratorio de Toxicología Ambiental, Departamento de Ciencias Ambientales, Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán, Ciudad de México 04510, México; Centro Nacional de Recursos Genéticos, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Tepatitlán de Morelos, 47600, Jalisco, México; Escuela Superior de Ciencias de la Tierra, Universidad Autónoma de Guerrero. Ex-hacienda de San Juan Bautista, Taxco el Viejo, 40323, Taxco el Viejo, Guerrero, México. Electronic address:
This study explored the distribution of macronutrients (Ca, Mg, Na, K) and lithogenic (Ba, Cr, Ni, Mn, Fe) and mining-related (As, Pb, Cd, Cu, Zn) toxic metalloids and metals (TMMs) in tomato (Solanum lycopersicum L.), and its effects on plant development, productivity, genotoxicity, and human health, using a soil affected by mine tailings (AS) and an unaffected control soil (CS). The chemistry of soils reflected their mineralogy, and Fe-Ti oxides, sulfides and sulfosalts were found to be the most significant reservoirs of TMMs.
View Article and Find Full Text PDFMigrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice.
Stem Cell Res Ther
January 2025
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, P. R. China.
Background: Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated in migrating cells and facilitate intercellular communication.
View Article and Find Full Text PDFInhibitory activity and mechanisms of chitosan against Fusarium avenaceum, a pathogen causing Angelica root rot disease.
Int J Biol Macromol
January 2025
College of Life Sciences, Northwest Normal University, Lanzhou 730070, China; Gansu Engineering Research Center of High Value-added Utilization of Distinctive Agricultural Products, Lanzhou 730070, China. Electronic address:
The polysaccharide chitosan possesses broad-spectrum antimicrobial properties and has proven effective in controlling various postharvest diseases in fruits. Nevertheless, the fundamental mechanisms underlying its action remain unclear. In this study, the antifungal effects of chitosan with different molecular weights against Fusarium avenaceum, a pathogen causing root rot in Angelica sinensis, were evaluated.
View Article and Find Full Text PDFLoss of flavonoids homeostasis leads to pistillody in sua-CMS of Nicotiana tabacum.
BMC Plant Biol
January 2025
School of Engineering, Dali University, Dali, Yunnan Province, China.
The homeotic transformation of stamens into pistil-like structures (pistillody) causes cytoplasmic male sterility (CMS). This phenomenon is widely present in plants, and might be induced by intracellular communication (mitochondrial retrograde signaling), but its systemic regulating mechanism is still unclear. In this study, morphological observation showed that the stamens transformed into pistil-like structures, leading to flat and dehiscent pistils, and fruit set decrease in sua-CMS (MS K326, somatic fusion between Nicotiana.
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