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Left ventricular outflow tract (LVOT) obstruction is mostly caused by hypertrophic obstructive cardiomyopathy and subaortic stenosis. Rarely, malignancy can lead to dynamic LVOT obstruction and has only been sporadically documented. We present the first case of dynamic and/or nearly fixed LVOT obstruction caused by a cardiac myxoid spindle cell sarcoma.

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Right ventricular remodeling in complex congenital heart disease.

Can J Cardiol

January 2025

Research Center, Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Canada; Adult Congenital Heart Centre, Montreal Heart Institute, Université de Montréal, Montreal, Canada. Electronic address:

In congenital heart diseases (CHD) of moderate to great complexity involving the right ventricle (RV), the morphologic RV can be exposed to significant stressors across the lifespan either in a biventricular circulation in a sub-pulmonary or sub-aortic position, or as part of a univentricular circulation. These include pressure and/or volume overload, hypoxia, ischemia, and periprocedural surgical stress leading to remodeling, maladaptation, dilation hypertrophy and dysfunction. This review examines the macroscopic remodeling of the RV in various forms of CHD and explores remodeling trajectories, along with the effects of surgeries and residual lesion repair, in tetralogy of Fallot, Ebstein anomaly, congenitally corrected transposition of the great arteries, transposition of the great arteries with atrial switch surgery, and single ventricle palliated by Fontan.

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Article Synopsis
  • Shone complex (SC) is a rare congenital heart disease involving four obstructive lesions in the left side of the heart, making up 0.6-0.7% of CHD cases.
  • A 4-week-old male neonate with SC presented severe respiratory distress and related symptoms, leading to a diagnosis that included multiple heart issues and a successful surgical intervention at five months.
  • Early detection through echocardiography and multidisciplinary care is crucial for effective management and improved patient outcomes in SC cases.
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Storytelling of Hypertrophic Cardiomyopathy Discovery.

J Cardiovasc Dev Dis

September 2024

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, 35121 Padova, Italy.

Article Synopsis
  • The discovery of hypertrophic cardiomyopathy (HCM) began in 1958 when Donald Teare noted cases of asymmetric ventricular septum hypertrophy during autopsies, linking sudden deaths to this condition.
  • The term "idiopathic hypertrophic subaortic stenosis" emerged in the late 1950s and highlighted the confusion between HCM and valve-related issues, as seen in cases managed by Eugene Braunwald and Andrew Glenn Morrow.
  • Over the decades, HCM has been classified and better understood, evolving from early notions of "functional subaortic stenosis" to a formal classification of cardiomyopathies established by John F. Goodwin and refined by the WHO, recognizing familial links and new types
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Article Synopsis
  • * Recent findings emphasize that the mitral valve, papillary muscle issues, and an apical-basal muscle bundle also contribute significantly to this obstruction, not just the typical septal hypertrophy.
  • * Four-dimensional computed tomography is recommended for detailed assessment and planning of surgical intervention in HCM, offering better imaging capabilities than traditional methods like echocardiography or cardiac MRI.
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