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The silent pandemic of stress: impact on menstrual cycle and ovulation.
Stress
December 2025
Division of General Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA.
In the current age of technological advancement, stress has emerged as a silent pandemic affecting individuals, especially young generations, globally. Factors such as increased competition, social pressures fueled by social media and smartphones, and a sense of diminished control in the face of modern challenges contribute to rising stress levels. In addition to the negative implications on mental well-being, stress affects physiological processes such as the menstrual cycle.
View Article and Find Full Text PDFGonadotropin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.
Cochrane Database Syst Rev
January 2025
Institute of Education in Healthcare and Medical Sciences, University of Aberdeen, Aberdeen, UK.
Background: Gonadotropin-releasing hormone agonists (GnRHa) are commonly used in assisted reproduction technology (ART) cycles to prevent a luteinising hormone (LH) surge during controlled ovarian hyperstimulation (COH) prior to planned oocyte retrieval, thus optimising the chances of live birth. We compared the benefits and risks of the different GnRHa protocols used.
Objectives: To evaluate the effectiveness and safety of different GnRHa protocols used as adjuncts to COH in women undergoing ART.
Article Synopsis
- Determining progesterone levels in mares' serum is crucial for identifying issues related to their estrus cycle or luteal insufficiency, but current methods lack quick, accurate results within two hours.
- This study assesses the effectiveness of the mini VIDAS device, a commercial enzyme-linked fluorescent assay, against the traditional radioimmunoassay (RIA) for progesterone measurement in mares.
- Results indicate a strong correlation between mini VIDAS and RIA measurements; however, the mini VIDAS may have limitations in precision at lower progesterone levels, which could affect diagnostic accuracy.
, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development.
Gut Microbes
November 2024
Biodiversity Research Center, Academia Sinica, Taipei, Taiwan.
Article Synopsis
- - Levels of progesterone increase after ovulation and are vital for supporting pregnancy, but gut microbiota can influence these levels by affecting the hormone's recycling in the liver and gut.
- - A specific gut bacterium plays a key role in metabolizing progesterone into a neurosteroid, which does not have progestogenic activity; researchers identified the enzyme responsible for this conversion.
- - In experiments with female mice, certain antibiotics helped restore progesterone levels, and prolonged antibiotic use disrupted ovarian follicle development, suggesting a link between gut bacteria and progesterone resistance in women.
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