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The Neurocircuitry of Substance Use Disorder, Treatment, and Change: A Resource for Clinical Psychiatrists.
Am J Psychiatry
November 2024
Division on Substance Use Disorders, New York State Psychiatric Institute, New York; Department of Psychiatry, Columbia University Irving Medical Center, New York.
Substance use disorder (SUD) is common in psychiatric patients and has a negative impact on health and well-being. However, SUD often goes untreated, and there is a need for psychiatrists, of all specialties, to address this pervasive clinical problem. In this review, the authors' goal is to provide a resource that describes treatments for SUD, using neuroscience as a framework.
View Article and Find Full Text PDFRapidly Trading Down Depression's 3 Pillars to 5HT3-Receptors Through ECT or Psilocybin?
Psychiatr Danub
September 2024
BipoSuisse - Psychiatrische Praxis, Vereinsweg 11, CH 3012 Berne, Switzerland,
Article Synopsis
- - Depression can potentially be alleviated instantly using electrotherapies or psychedelics like psilocybin, shifting focus from traditional antidepressant approaches that overlook the importance of the serotonin channel 5HT3.
- - The text introduces three main factors, or "pillars," contributing to depression: mitochondria's influence via 5HT3, neurobiological "pushback" effects shown in brain imaging, and psychological elements like shame and conflict, possibly linked to brain-ganglia interactions.
- - It suggests that psychedelics may help combat neurobiological issues linked to depression by interacting with certain serotonin channels, and draws parallels between the evolution of psilocybin in fungi and its potential anti-depressive
[Feeling unwell after eating a piece of chocolate].
Ned Tijdschr Geneeskd
November 2023
Isala, Zwolle: Afd. Apotheek.
Background: Since 2006 chocolate containing psilocin is circulating in The Netherlands. Psilocin is a psychoactive substance derived from psychedelic mushrooms and known to be hard drugs. Consuming psilocin can cause symptoms such as hallucinations, fear and panic attacks and sympathomimetic effects.
View Article and Find Full Text PDFPsilocybin intoxication did not affect daytime or sleep-related declarative memory consolidation in a small sample exploratory analysis.
Eur Neuropsychopharmacol
September 2023
Psychedelic Research Centre, National Institute of Mental Health, Topolová 748, Klecany, 250 67, Czech Republic; 3rd Faculty of Medicine, Charles University, Ruská 87, Prague 10, 100 00, Czech Republic. Electronic address:
Psilocybin is investigated as a fast-acting antidepressant used in conjunction with psychotherapy. Intact cognitive functions, including memory, are one of the basic conditions of effective psychedelic-assisted therapy. While cognitive and memory processing is attenuated on various domains during psilocybin intoxication, the effect of psilocybin on the consolidation of memories learned outside of acute intoxication is not known.
View Article and Find Full Text PDFAcute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats-pharmacokinetics, effects on behaviour and thermoregulation.
Front Pharmacol
March 2023
Psychedelics Research Centre, National Institute of Mental Health, Prague, Czechia.
-2-methoxy-benzylated ("NBOMe") analogues of phenethylamine are a group of new psychoactive substances (NPS) with reported strong psychedelic effects in sub-milligram doses linked to a number of severe intoxications, including fatal ones. In our present work, we provide a detailed investigation of pharmacokinetics and acute behavioural effects of 2C-B-Fly-NBOMe (2-(8-bromo-2,3,6,7-tetrahydrobenzo [1,2-b:4,5-b']difuran-4-yl)-[(2-methoxybenzyl]ethan-1-amine), an analogue of popular psychedelic entactogen 2C-B (4-Bromo-2,5-dimethoxyphenethylamine). All experiments were conducted on adult male Wistar rats.
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