Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0024-3205(80)90339-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy.
Bioorg Med Chem
January 2022
LAQV and REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal. Electronic address:
Colorectal cancer (CRC) is the third most detected cancer and the second foremost cause of cancer deaths in the world. Intervention targeting p53 provides potential therapeutic strategies, but thus far no p53-based therapy has been successfully translated into clinical cancer treatment. Here we developed a Quantitative Structure-Activity Relationships (QSAR) classification models using empirical molecular descriptors and fingerprints to predict the activity against the p53 protein, using the potency value with the active or inactive label, were developed.
View Article and Find Full Text PDF[Assessment of quality of life and treatment adherence in patients with dizziness treated with vasobral].
Zh Nevrol Psikhiatr Im S S Korsakova
June 2019
LLC Chiesi Pharmaceuticals, Moscow, Russia.
Aim: To study indicators of quality of life and adherence to treatment with vazobral in patients with dizziness of vascular genesis.
Material And Methods: Vazobral was administered to 330 patients with vertigo due to cerebrovascular disease for 3 months during a non-inferiority, open-label study. Quality of life (measured using VAS and the second part of the EQ-5D questionnaire), severity and frequency of dizziness attacks (using VAS), the overall effectiveness of treatment on the basis of objective (according to the doctor) and subjective (using CGI) assessments, treatment adherence were evaluated.
Dihydroergotoxine mesylate for the treatment of sialorrhea in Parkinson's disease.
Parkinsonism Relat Disord
January 2019
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China. Electronic address:
Background: Many patients with Parkinson's disease (PD) suffer from sialorrhea. Sialorrhea is often treated with anticholinergics and botulinum toxin, but some adverse effects have limited the use of these treatments. Dihydroergotoxine mesylate is an α-adrenergic blocking agents as well as some affinities to the dopaminergic and serotonin (5-HT) receptors.
View Article and Find Full Text PDFMiscellaneous treatments for antipsychotic-induced tardive dyskinesia.
Cochrane Database Syst Rev
March 2018
Editorial & Methods Department, Cochrane, St Albans House, 57 - 59 Haymarket, London, UK, SW1Y 4QX.
Background: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. This review, one in a series examining the treatment of TD, covers miscellaneous treatments not covered elsewhere.
View Article and Find Full Text PDF[Effects of Tongluo Xingnao effervescent tablets on blood rheology, iNOS, VEGF and LDH-5 in MID rats].
Zhongguo Zhong Yao Za Zhi
March 2016
China Academy of Traditional Chinese Medicine, Beijing 100700, China.
The study was to explore effects of Tongluo Xingnao effervescent tablets on the blood rheology, iNOS, VEGF and LDH-5 in multi-infarct dementia(MID) model rats. Establish MID model rats were induced by microthrombosis, from which 50 successful model rats were randomly divided into five groups, such as the model control group, the dihydroergotoxine mesylate tablets(hydergine) group(0.7 mg•kg⁻¹), Tongluo Xingnao effervescent tablets high-dose, medium-dose and low-dose groups(7.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!