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Well-differentiated neuroendocrine tumors of the appendix: Diagnosis, differentials, and disease progression.

Semin Diagn Pathol

September 2024

Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, United States. Electronic address:

Well-differentiated neuroendocrine tumors are the most common neoplasm of the appendix. They are graded and staged using World Health Organization and American Joint Committee on Cancer criteria, respectively. They may be invisible grossly or form rounded yellow nodules, sometimes in the appendiceal tip.

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Colonic lymphangiomas are rare and mostly incidental findings found on colonoscopy. It is important to be able to differentiate them from other lesions, such as lipomas. Furthermore, when in close proximity to the appendiceal orifice, such as cecal lesions, they must be differentiated from mucocele and carcinoid tumors.

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Intussusception is a prominent contributor to bowel obstruction, marked by the invagination of a proximal bowel section into a distal segment. Ileocecal intussusception occurs when a portion of the terminal ileum folds into the cecum. In adults, intussusception is infrequent compared to pediatric cases, and represents a minority of bowel obstructions.

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Objective: To evaluate the association between clinical and imaging with surgical and pathological findings in patients with suspected neuroendocrine tumor of appendix and/or appendix endometriosis.

Methods: Retrospective descriptive study conducted at the Teaching and Research Institute of , in which medical records and databases of patients with suspected neuroendocrine tumor of appendix and/or endometriosis of appendix were analyzed by imaging.

Results: Twenty-eight patients were included, all of which had some type of appendix alteration on the ultrasound examination.

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Background: The risk-benefit balance of prophylactic appendectomy in patients undergoing left colorectal cancer resection is unclear. The aim of this report is to assess the proportion of histologically abnormal appendices in patients undergoing colorectal cancer resection in a unit where standard of care is appendectomy, with consent, when left-sided resection is performed.

Methods: A retrospective study on a prospectively collected database was conducted in a single tertiary-care center.

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