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Comparison of (99m)Tc-HEPIDA and (99m)Tc-MBrIDA from the standpoint of hepatic clearance determination-- preliminary communication.
Nucl Med Rev Cent East Eur
June 2010
Department of Nuclear Medicine, Medical University of Lodz, Poland.
BACKGROUND. In order to evaluate the functional capacity of the liver by means of clearance determination, the derivative of iminodiacetic acid ((99m)Tc-HEPIDA) has been used in recent decades. Because of recent problems with manufacturing and delivery of (99m)Tc-HEPIDA, an investigation was undertaken with the aim of testing whether a more widely available (99m)Tc-MBrIDA could be used for clearance determination and whether hepatic clearance measured with the use of this compound provides a similarly useful test of hepatic function.
View Article and Find Full Text PDF(99m)Tc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of a single sample plasma and hepatic clearance of (99m)Tc-HEPIDA for assessment of hepatic parenchyma performance.
Nucl Med Rev Cent East Eur
June 2007
Nuclear Medicine Department, Central University Hospital, ul. Czechoslowacka 8-10, 92-216 Łódź, Poland.
Background: A simplified method of (99m)Tc-HEPIDA clearance determination, both plasma and hepatic, depends upon measuring the radiopharmaceutical concentration in plasma of a blood sample taken once in the time range from 68-83 min after injection of compound, and measurement of activity voided (excreted) with urine about five minutes after blood sampling. The aim of the present study was to analyze the clinical usefulness of both clearances, as determined by the simplified method in view of the diagnostic usefulness of both clearances (particularly of hepatic clearance) as determined by the respective multisampling method.
Material And Methods: For the analysis, archived data of studies in 134 individuals (48 healthy individuals and 86 patients with chronic liver parenchyma damage) were used, in which plasma clearance (Cl(Pl)) and hepatic clearance (Cl(Hp)) (99m)Tc -HEPIDA were determined by the standard multisample method--the values of such determined clearances constituted clearance referential values for further comparative analyses.
99mTc-HEPIDA hepatic clearance as a diagnostic tool: usefulness of plasma and hepatic clearance for assessment of hepatic parenchyma performance.
Nucl Med Rev Cent East Eur
April 2004
Nuclear Medicine Department of the Medical University, Łódź, Poland.
Plasma clearance of (99m)Tc-HEPIDA (Cl(Pl)) has been used for two decades for assessment of liver function in patients with diseases of this organ. A specific determination of (99m)Tc-HEPIDA liver clearance (Cl(Hp)) has been developed that provides more direct possibility to evaluate performance of liver parenchyma. Both tests have been studied in healthy volunteers of varying age (48 individuals) and in 83 patients with varying degree of liver damage.
View Article and Find Full Text PDFDuodenogastric reflux: clinical and therapeutic aspects.
Arch Dis Child
July 1999
Department of Paediatrics, Paediatric Gastroenterology and Oncology, Medical University of Gdañsk, ul. Nowe Ogrody 1/6, 80-803 Gdañsk, Poland.
Background: Duodenogastric reflux is believed to cause damage to gastric mucosa. Most reports on this disorder concern adult patients.
Patients And Methods: 1120 children with abdominal pain were studied; endoscopic features of duodenogastric reflux were found in 92 patients.
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