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Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms.
Sci Rep
June 2024
Graduate School of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Parameter optimization (PO) methods to determine the ionic current composition of experimental cardiac action potential (AP) waveform have been developed using a computer model of cardiac membrane excitation. However, it was suggested that fitting a single AP record in the PO method was not always successful in providing a unique answer because of a shortage of information. We found that the PO method worked perfectly if the PO method was applied to a pair of a control AP and a model output AP in which a single ionic current out of six current species, such as I, I, I, I, I or I was partially blocked in silico.
View Article and Find Full Text PDFMolecular dissection of ALS-linked TDP-43 - involvement of the Gly-rich domain in interaction with G-quadruplex mRNA.
FEBS Lett
July 2020
Department of Biological Science, Graduate School of Science, and Faculty of Science Osaka University, Toyonaka, Japan.
TDP-43 is the major pathogenic protein of amyotrophic lateral sclerosis (ALS). Previously, we identified that TDP-43 interacts with G-quadruplex (G4)-containing RNA and is involved in their long-distance transport in neurons. For the molecular dissection of the TDP-43 and G4-RNA interaction, we analyzed it here in vitro and in cultured cells using a set of 10 mutant TDP-43 proteins from familial and sporadic ALS patients as well as using the TDP-43 C-terminal Gly-rich domain alone.
View Article and Find Full Text PDFDissection of morphological and metabolic differentiation of ameloblasts via ectopic SP6 expression.
J Med Invest
July 2012
Department of Molecular Biology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
Tooth enamel is the hardest organ in the body. In rodent incisor, the enamel is exclusively produced by ameloblasts with yellowish-brown pigmentation, indicating normal enamel formation. However, the molecular mechanisms of ameloblast differentiation and amelogenesis are not fully understood.
View Article and Find Full Text PDFCorrelation between reduction of syndecan-1 expression and clinico-pathological parameters in squamous cell carcinoma of tongue.
Int J Oral Maxillofac Surg
March 2006
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, 1-2-2, Masago, Mihama-ku, Chiba 261-8502, Japan.
We examined expression of syndecan-1 in squamous cell carcinoma (SCC) of tongue using immunohistochemistry. Forty-three cases of SCC arising in lateral border of tongue were investigated. From the immunohistochemical staining pattern, the cases were divided into two groups based on expression of syndecan-1 at the supra-peripheral cells of the tumor nest: Group A, completely or mainly positive; Group B, sporadically positive or negative.
View Article and Find Full Text PDFOral fungal and bacterial infections in HIV-infected individuals: an overview in Africa.
Oral Dis
November 2002
Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK.
Oral opportunistic infections developing secondary to human immunodeficiency virus (HIV) infection have been reported from the early days of the epidemic and have been classified by both the EC-Clearinghouse and the World Health Organisation (WHO). Among the fungal infections, oral candidiasis, presenting in African HIV-infected patients has been sporadically documented. We review the literature with respect to candidal carriage, oral candidiasis prevalence and the predictive value of oral candidiasis for a diagnosis of underlying HIV disease in African HIV-infected patients.
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