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(FEV-FEV)/FVC: A Terminal-Airflow Variable for Airway Hyperresponsiveness and Inflammation Prediction in Patients With Symptoms Despite Preserved Spirometry.
J Allergy Clin Immunol Pract
January 2025
Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Background: Small-airway function assessment is crucial for asthma diagnosis and management. Abnormalities in terminal airflow deserve attention.
Objective: This study investigated whether (FEV-FEV)/FVC correlates with airway hyperresponsiveness (AHR) and inflammation in patients with preserved spirometry.
Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation.
J Clin Invest
October 2024
Department of Pathology, Microbiology, and Immunology.
Female individuals have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway inflammation, and Th17 cells rely on glutaminolysis. However, it remains unclear whether androgen receptor (AR) signaling modifies glutamine metabolism to suppress Th17 cell-mediated airway inflammation.
View Article and Find Full Text PDFAre the Reference Values for the Provocative Concentration of Methacholine Appropriate for Children?
J Aerosol Med Pulm Drug Deliv
October 2024
Trudell Medical International, London, Canada.
Preliminary data in a randomly selected pediatric cohort study in 8-year-olds suggested a rate of positivity to a methacholine challenge test that was unexpectedly high, roughly 30%. The current recommendation for a negative methacholine test is a 20% decrease in the forced expiratory volume in one second at a dose greater than 400 μg. This was derived from studies in adults using the obsolete English Wright nebulizer.
View Article and Find Full Text PDFThe Abbreviated Methacholine Challenge Test is Safe for Children.
J Pediatr
January 2025
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheba, Israel.
Objective: To evaluate the safety of an abbreviated methacholine challenge test (MCT) protocol in children.
Study Design: This prospective, observational study enrolled children aged 6 through 18 years referred for the MCT. The abbreviated protocol was initiated with a methacholine dose of 0.
Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans.
Respir Res
August 2024
Dipartimento di Medicina Sperimentale, Università di Genova, 16132, Genova, Italy.
Background: Increasing functional residual capacity (FRC) or tidal volume (V) reduces airway resistance and attenuates the response to bronchoconstrictor stimuli in animals and humans. What is unknown is which one of the above mechanisms is more effective in modulating airway caliber and whether their combination yields additive or synergistic effects. To address this question, we investigated the effects of increased FRC and increased V in attenuating the bronchoconstriction induced by inhaled methacholine (MCh) in healthy humans.
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