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Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks.
J Exp Med
April 2025
Department of Immunology, Harvard Medical School, Boston, MA, USA.
Inflammatory cytokines are fundamental mediators of the organismal response to injury, infection, or other harmful stimuli. To elucidate the early and mostly direct transcriptional signatures of inflammatory cytokines, we profiled all immunologic cell types by RNAseq after systemic exposure to IL1β, IL6, and TNFα. Our results revealed a significant overlap in the responses, with broad divergence between myeloid and lymphoid cells, but with very few cell-type-specific responses.
View Article and Find Full Text PDFAlternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in mice.
Life Metab
June 2024
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due to its metabolic benefits. However, the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal models.
View Article and Find Full Text PDFGreen building development utilising modified fired clay bricks and eggshell waste.
Sci Rep
January 2025
PV Unit, Solar and Space Research Department, National Research Institute of Astronomy and Geophysics (NRIAG), Helwan, Cairo, Egypt.
The inadequate thermal insulation of the building envelope contributes significantly to the high power consumption of air conditioners in houses. A crucial factor in raising a building's energy efficiency involves utilizing bricks with high thermal resistance. This issue is accompanied by another critical challenge: recycling and disposing of waste in a way that is both economically and environmentally beneficial, including using it to fuel industrial growth, in order to reduce the harmful effects of waste on the environment as waste generation in our societies grows.
View Article and Find Full Text PDFPhotochemical Evolution of Alanine in Association with the Martian Soil Analog Montmorillonite: Insights Derived from Experiments Conducted on the International Space Station.
Astrobiology
January 2025
Experimental Biophysics and Space Sciences, Department of Physics, Freie Universitaet Berlin, Berlin, Germany.
The (PSS) experiment was part of the European Space Agency's mission and was conducted on the International Space Station from 2014 to 2016. The PSS experiment investigated the properties of montmorillonite clay as a protective shield against degradation of organic compounds that were exposed to elevated levels of ultraviolet (UV) radiation in space. Additionally, we examined the potential for montmorillonite to catalyze UV-induced breakdown of the amino acid alanine and its potential to trap the resulting photochemical byproducts within its interlayers.
View Article and Find Full Text PDFInterspecies interactions mediated by arginine metabolism enhance the stress tolerance of against .
Microbiol Spectr
January 2025
School of Pharmacy, Lanzhou University, Lanzhou, China.
Colorectal cancer (CRC) is a common cancer accompanied by microbiome dysbiosis. Exploration of probiotics against oncogenic microorganisms is promising for CRC treatment. Here, differential microorganisms between CRC and healthy control were analyzed.
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