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Proton pump inhibitors and all-cause mortality risk among cancer patients.
World J Clin Oncol
January 2025
Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States.
Background: Proton pump inhibitors (PPIs) are widely used, including among cancer patients, to manage gastroesophageal reflux and other gastric acid-related disorders. Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes, including greater mortality.
Aim: To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.
The OCT2/MATE1 Interaction Between Trifluridine, Metformin and Cimetidine: A Crossover Pharmacokinetic Study.
Clin Pharmacokinet
July 2024
Department of Medical Oncology, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Background And Objectives: Trifluridine/tipiracil, registered for the treatment of patients with metastatic gastric and colorectal cancer, is a substrate and inhibitor for the organic cation transporter 2 (OCT2) and the multidrug and toxin extrusion protein 1 (MATE1), which raises the potential for drug-drug interactions with other OCT2/MATE1 modulators. Therefore, we prospectively examined the effect of an OCT2/MATE1 inhibitor (cimetidine) and substrate (metformin) on the pharmacokinetics of trifluridine.
Methods: In this three-phase crossover study, patients with metastatic colorectal or gastric cancer were sequentially treated with trifluridine/tipiracil alone (phase A), trifluridine/tipiracil concomitant with metformin (phase B) and trifluridine/tipiracil concomitant with cimetidine (phase C).
Poisoning cases and their management in Amhara National Regional State, Ethiopia: Hospital-based prospective study.
PLoS One
May 2024
Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Article Synopsis
- Poisoning is a major public health concern in Ethiopia, with a study showing that out of 442 cases, 78 (17.6%) resulted in death, predominantly from intentional self-poisoning.
- The most common poisons were organophosphate compounds and aluminum phosphide, most often sourced from patients' homes or local shops.
- Key factors influencing poor treatment outcomes included altered consciousness upon hospital arrival, poisoning from metal phosphides, and lack of laboratory investigations.
Evaluation of Gastroprotective Activity of the Methanolic Extract of Jacq. (Acanthaceae).
Nutrients
May 2024
Postgraduate Program in Pharmaceutical Sciences, Pharmacology and Therapeutics, Evangelical University of Goiás-Unievangélica, University Avenue Km 3,5, Anápolis 75083-515, GO, Brazil.
Introduction: Jacq. is traditionally applied in folk medicine in Brazil and in several Latin American countries. The leaves are used in tea form, especially in the treatment of respiratory disorders, acting as an expectorant.
View Article and Find Full Text PDFCimetidine Attenuates Therapeutic Effect of Anti-PD-1 and Anti-PD-L1 and Modulates Tumor Microenvironment in Colon Cancer.
Biomedicines
March 2024
Department of Medical Research, MacKay Memorial Hospital, New Taipei City 251020, Taiwan.
Histamine modulates immunity by binding to histamine receptor 2 (H2R). Cimetidine, an H2R antagonist that inhibits gastric acid secretion and treats gastrointestinal ulcers, interferes with histamine-mediated immunomodulation and may have anticancer activity. This study examined cimetidine's effect on the anticancer effect of anti-PD-L1 in colon cancer.
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