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Metabolic shifts in glioblastoma: unraveling altered pathways and exploring novel therapeutic avenues.
Mol Biol Rep
January 2025
Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, UP, 201309, India.
Metabolic reprogramming stands out as a defining characteristic of cancer, including glioblastoma (GB), enabling tumor cells to overcome growth and survival challenges in adverse conditions. The dysregulation of metabolic processes in GB is crucial to its pathogenesis, influencing both tumorigenesis and the disease's invasive tendencies. This altered metabolism supplies essential energy substrates for uncontrolled cell proliferation and also creates an immunosuppressive microenvironment, complicating conventional therapies.
View Article and Find Full Text PDFInsights into Landscape Structure Change in Urbanising Rainforest and Guinea Savanna Ecological Regions of Nigeria.
Environ Manage
January 2025
Department of Geoecology, Institute of Geosciences and Geography, Martin Luther University, Halle-Wittenberg, Halle (Saale), Germany.
In the face of unabated urban expansion, understanding the intrinsic characteristics of landscape structure is pertinent to preserving ecological diversity and managing the supply of ecosystem services. This study integrates machine-learning-based geospatial and landscape ecological techniques to assess the dynamics of landscape structure in cities of the rainforest (Akure and Owerri) and Guinea savanna (Makurdi and Minna) ecological regions of Nigeria between 1986 and 2022. Supervised classification using the random forest (RF) machine-learning classifier was performed on Landsat images on the Google Earth Engine (GEE) platform, and landscape metrics were calculated with FRAGSTATS to assess landscape composition, configuration, and connectivity.
View Article and Find Full Text PDFDouble-Dynamic-Bond Cross-Linked Hydrogel Adhesive with Cohesion-Adhesion Enhancement for Emergency Tissue Closure and Infected Wound Healing.
Adv Healthc Mater
January 2025
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
The hydrogel adhesives with strong tissue adhesion and biological characteristics adhm202404447are urgently needed for injury sealing and tissue repair. However, the negative correlation between tissue adhesion and the mechanical strength poses a challenge for their practical application. Herein, a bio-inspired cohesive enhancement strategy is developed to prepare the hydrogel adhesive with simultaneously enhanced mechanical strength and tissue adhesion.
View Article and Find Full Text PDFDynamic analysis of growth characteristics, secondary metabolites accumulation, and an in-depth understanding of anthraquinones biosynthesis in Linn.
Front Plant Sci
January 2025
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
is a well-known plant used in oriental medicine plant, and is also serves as the primary traditional source of plant red dyestuffs. With the current depletion of natural resources of , it is critical to conduct cultivation studies on the . Here, we report on the dynamic growth characteristics and secondary metabolite accumulation of cultivated , as well as the discovery of important genes involved in anthraquinone biosynthesis.
View Article and Find Full Text PDFIntegrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis.
Front Genet
January 2025
Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Objectives: Unlike other diseases, cancer is not just a genome disease but should broadly be viewed as a disease of the cellular machinery. Therefore, integrative multifaceted approaches are crucial to understanding the complex nature of cancer biology. Bcl-2 (B-cell lymphoma 2), encoded by the human BCL-2 gene, is an anti-apoptotic molecule that plays a key role in apoptosis and genetic variation of Bcl-2 proteins and is vital in disrupting the apoptotic machinery.
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