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TRPS1 is a useful marker in differentiating metastatic breast carcinoma from pancreatic adenocarcinoma in fine-needle aspiration specimens.
Am J Clin Pathol
December 2024
Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, US.
Objectives: Distinction of metastatic breast carcinoma (BC) to the pancreas from primary pancreatic adenocarcinoma (PAC) is essential but challenging. Breast carcinoma shares similar morphology and exhibits an overlapping immunohistochemistry (IHC) profile with PAC. We investigated the utility of recently reported trichorhinophalangeal syndrome type 1 (TRPS1) IHC in differentiating metastatic BC from PAC in fine-needle aspiration (FNA) specimens.
View Article and Find Full Text PDFTRPS1 expression in cytologic specimens of salivary duct carcinoma and other salivary gland tumors.
Ann Diagn Pathol
February 2025
Department of Pathology, Albany Medical Center, Albany Medical College, Albany, NY, USA.
Recent studies suggest that trichorhinophalangeal syndrome type 1 (TRPS1) is sensitive immunomarker for breast carcinoma (BC). Salivary duct carcinoma (SDC) of salivary gland can share similar morphologic and immunophenotypic features with BC. This study aimed to assess the expression of TRPS1 in SDC and other salivary gland tumors (SGTs).
View Article and Find Full Text PDFA Comprehensive Review of TRPS1 as a Diagnostic Immunohistochemical Marker for Primary Breast Carcinoma: Latest Insights and Diagnostic Pitfalls.
Cancers (Basel)
October 2024
Department of Genetics, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Background/objectives: Immunohistochemical expression of TRPS1 (trichorhinophalangeal syndrome type 1) protein is usually used by pathologists to confirm breast origin for triple-negative breast cancers (TNBC) or metastatic carcinomas of unknown primary. However, recent studies have reported TRPS1 expression in a variety of non-breast lesions. This review aims to provide a comprehensive evaluation of TRPS1 expression across various tumor types, highlighting both its diagnostic utility and potential pitfalls that may arise in clinical practice.
View Article and Find Full Text PDFExpression of TRPS1 in Metastatic Tumors of the Skin: An Immunohistochemical Study of 72 Cases.
Dermatopathology (Basel)
October 2024
Laboratory of Pathology, Lyon-Sud Hospital Center, 69495 Pierre Bénite, France.
(Tricho-rhino-phalangeal syndrome 1) is a GATA transcriptional activator gene encoding for a protein used as a sensitive immunohistochemical marker of breast carcinomas. In dermatopathology, TRPS1 is used as a marker of mammary and extramammary Paget's disease and is also expressed by a variety of primary cutaneous tumors, mostly of adnexal origin. So far, very limited data exist on the expression of TRPS1 in metastatic skin tumors.
View Article and Find Full Text PDFWhen an Overwhelming Number of Supernumerary Teeth Provides an Alternative to the Diagnosis of Trichorhinophalangeal Syndrome.
Case Rep Dent
October 2024
Oral & Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
The prevalence of supernumerary teeth is increasing in modern dental practice. However, the presence of multiple supernumerary teeth should be further investigated. Proper diagnosis of an underlying syndrome might save the patient from future health hazards through early diagnosis and optimal follow-up screening.
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