The anti-inflammatory activity of 6-methoxyindan-1-acetic acid (1a) and 5,6-dimethoxyindan-1-acetic acid (1b) was evaluated in various acute, subacute and chronic models of inflammation. The results of these studies suggest that they have equal or slightly more anti-inflammatory activity than phenylbutazone, a standard anti-inflammatory drug. Of the two compounds, 5,6-dimethoxyindan-l-acetic acid appeared to be slightly more active than 6-methoxyindan-l-acetic acid.
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