Normal mouse sera from non-immunized individuals of different strains gave high titres of "natural" antibodies which agglutinated RBC's of different inbred lines of chickens. Normal mouse sera of A strain and its congenic lines agglutinated RBC's of all chicken lines whereas normal sera of B10 strain and its congenic lines did not react with RBC's of Iowa A line. Normal sera of other mouse strains behaved similarly. The different reactivity of the congenic chicken lines IA and IC, which are identical in the B complex (MHC) and differ only in erythrocyte antigens of the A blood group system, suggests that natural antibodies may also react with antigens other than the chicken MHC antigens. On the other hand, normal sera from chickens of inbred lines reacted with all erythrocytes of the different mouse strains tested.
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