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Analysis of MLKL, RIP1 and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis.
Viruses
December 2024
Departmento of Pathology, Evandro Chagas Institute, Ministry of Health, Ananindeua 67030-000, PA, Brazil.
Necroptosis is a regulated form of cell death implicated in several pathological conditions, including viral infections. In this study, we investigated the expression and correlation of necroptosis markers MLKL, RIP1 and RIP3 in human liver tissue from fatal cases of yellow fever (YF) using immunohistochemistry (IHC). The liver samples were obtained from 21 YF-positive individuals and five flavivirus-negative controls with preserved liver parenchymal architecture.
View Article and Find Full Text PDFDifferentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.
bioRxiv
December 2024
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Over the past two decades, rapid advancements in magnetic resonance technology have significantly enhanced the imaging resolution of functional Magnetic Resonance Imaging (fMRI), far surpassing its initial capabilities. Beyond mapping brain functional architecture at unprecedented scales, high-spatial-resolution acquisitions have also inspired and enabled several novel analytical strategies that can potentially improve the sensitivity and neuronal specificity of fMRI. With small voxels, one can sample from different levels of the vascular hierarchy within the cerebral cortex and resolve the temporal progression of hemodynamic changes from parenchymal to pial vessels.
View Article and Find Full Text PDFArtificial intelligence and stroke imaging.
Curr Opin Neurol
February 2025
High Dimensional Neurology Group, UCL Queen Square Institute of Neurology, University College London, Russell Square House, Bloomsbury, London, UK.
Article Synopsis
- The review highlights the complexity of stroke, driven by disruptions in blood supply and complicated by the neural and vascular systems' interactions.
- Advances in machine vision and deep learning are improving predictive tools for stroke, but their clinical impact is limited by real-world data challenges.
- Although AI's potential benefits for stroke care are clear, the best approaches for practical application are still being explored, with deep generative models seen as a promising avenue for innovation.
Potential anti-schistosomal effect of Daflon, a repurposed drug targeting different stages of Schistosome maturity.
Parasitol Res
November 2024
Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Despite the long history of experimental trials to combat schistosomiasis, it remains a significant burden due to drug resistance and the effectiveness of the standard treatment only against the mature stage, while skipping other early developmental stages thus leading to severe permanent pathological sequelae. Therefore, repurposing a commonly used well-known safe drug would be a wise alternative. We investigated the potential anti-schistosomal drug activity of Daflon® (DAF) against different schistosomal developmental stages.
View Article and Find Full Text PDFThe Dawn of Precision Medicine in Fibrotic Interstitial Lung Disease.
Chest
November 2024
Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL. Electronic address:
Article Synopsis
- * Recent advancements in precision medicine have led to the discovery of biomarkers and endotypes that can help differentiate patients with different forms of fibrotic ILDs and tailor treatments accordingly.
- * Despite progress in this field, there are still significant barriers—like infrastructure and regulatory issues—that need to be addressed before precision medicine can be widely implemented in clinical practice, which could enhance patient outcomes and quality of life.
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