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The natural flavonoid pinocembrin shows antithrombotic activity and suppresses septic thrombosis.
Int Immunopharmacol
December 2024
Division of Cardiology, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Sepsis, an extreme host response to systemic infection, remains one of the leading causes of mortality worldwide. Platelets, which are integral to both thrombosis and inflammation, play a crucial role in the pathophysiology of sepsis. Excessive platelet activation and aggregation significantly increase the risk of thrombosis, thereby elevating mortality in septic patients.
View Article and Find Full Text PDFEpinephrine induced lactic acidosis during the management of anaphylactic shock: a case report.
Clin Exp Emerg Med
May 2024
Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, Republic of Korea.
In a case of contrast media-induced anaphylactic shock managed with epinephrine, a 57-year-old male developed lactic acidosis without cardiogenic shock or global hypoperfusion, highlighting epinephrine's potential to trigger lactic acidosis. Despite previous management of similar reactions with antihistamines and corticosteroids, this case required intensive care unit admission and emergency intervention, with lactate levels peaking alarmingly. The rapid resolution of acidosis following epinephrine discontinuation underscores the need for careful monitoring and the consideration of alternative vasopressor strategies in severe anaphylaxis, illustrating the complex relationship between epinephrine's metabolic effects and anaphylaxis-induced tissue hypoperfusion.
View Article and Find Full Text PDFStress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop.
Exp Mol Med
May 2024
Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China.
Hepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was a potential therapeutic target in HCC. However, the mechanisms that lead to the upregulation of PLAGL2 in HCC remain unclear.
View Article and Find Full Text PDFHigh platelet adrenergic activity and concomitant activation of the pituitary/medullar axis as alarming laboratory parameters in ACS survivors-the STRESS-AMI study.
Front Cardiovasc Med
February 2024
Department of Cardiology, Central Hospital of Northern Pest-Military Hospital, Budapest, Hungary.
Introduction: Kinetics of stress-related biological parameters were determined in acute coronary syndrome (ACS) patients undergoing complex cardiovascular rehabilitation.
Methods: We determined platelet functionality in the absence/presence of a selective alpha-2 adrenergic receptor inhibitor, atipemazole parallel with salivary cortisol levels at enrolment, and at 3- and 12-months follow-up in 75 ACS patients with percutaneous coronary intervention.
Results: Pharmacological/non-pharmacological secondary prevention methods have been efficiently applied.
Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis.
Front Pharmacol
October 2023
Laboratory of Molecular Cardiology, Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation and explored the effect of luteolin on thrombosis, coagulation, and platelet production . Washed human platelets were used for aggregation, membrane protein expression, ATP, Ca, and LDH release, platelet adhesion/spreading, and clot retraction experiments.
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