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Dynamic reciprocal morphological changes in insect hosts and bacterial symbionts.
J Exp Biol
January 2025
Emory University, 1510 Clifton Road NE Atlanta, USA.
Symbiotic interactions, central to most life on Earth, are interwoven associations that vary in intimacy and duration. Some of the most well-known examples of symbioses occur between animals and gut bacteria. These associations lead to physiological integration of host and symbionts.
View Article and Find Full Text PDFExosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma.
Front Oncol
January 2025
School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Multiple Myeloma (MM) is the second most common malignancy of the hematopoietic system, accounting for approximately 10% of all hematological malignancies, and currently, there is no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in the initiation and progression of tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, and lncRNA-RNA binding proteins (RBP). Despite the significant clinical application potential of exosomal lncRNAs, research in this area still faces challenges due to their low abundance and technical limitations.
View Article and Find Full Text PDFBackground: Previous studies have suggested that changes in the composition of the extracellular matrix (ECM) play a significant role in the development of ligamentum flavum hypertrophy (LFH) and the histological differences between the ventral and dorsal layers of the hypertrophied ligamentum flavum. Although LFH is associated with increased fibrosis in the dorsal layer, comprehensive research exploring the characteristics of the ECM and its mechanical properties in both regions is limited. Furthermore, the distribution of fibrosis-associated myofibroblasts within LFH remains poorly understood.
View Article and Find Full Text PDFEnter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease.
F1000Res
January 2025
Immunology, University of Toronto, Toronto, Ontario, Canada.
Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease. Fibroblasts regulate the composition of the extracellular matrix (ECM), a 3-dimensional network of macromolecules that comprise the acellular milieu of tissues. Fibroblasts can directly and indirectly regulate immune responses by secreting ECM and ECM-bound molecules to shape tissue structure and influence organ function.
View Article and Find Full Text PDFExperimental support for partial compensation, not matched, partner response rules in blue tits.
Behav Ecol
December 2024
Centre for Ecology and Conservation, University of Exeter, Treliever Road, Penryn, Cornwall TR10 9FE, United Kingdom.
Outcomes of theoretical models on conflict resolution between investing partners in bi-parental care systems typically predict "partial compensation" or "matched" response rules, depending on underlying assumptions. Further, although experimental tests in birds suggest that care levels by pair members are largely associated with partial compensation responses, this outcome partly depends on the type of experiment used and its effects on model assumptions. To elucidate support for both the underlying assumptions and predictions of models predicting partner compensation versus matching, we performed temporary, bi-directional brood size manipulations during late nestling provisioning in blue tits () in the French Pyrenees.
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