Quantitative analysis of histological preparations of the rectal mucosa were carried out in 52 patients with gastrointestinal symptoms. Follow-up investigation demonstrated no signs of chronic inflammatory bowel disease. The variables recorded in the histological preparations in the 52 patients were the diameter (minor axis) of 10 consecutive, transversally cut glands, the space of lamina propria between glands, the number of glands per high-power field, and the number of nuclei in 10 consecutive areas of lamina propria (between glands). The histological state of the rectal mucosa in individual patients was quantitatively defined as the score resulting from the sum of the values in each of the above-mentioned variables. Similarly to the rectal mucosa from asymptomatic patients, the rectal mucosa from the 52 symptomatic patients had scores of 21 or less. These composite data form the basis for a comparative quantitative study of the rectal mucosa from patients with various chronic inflammatory conditions of the rectum.
Download full-text PDF |
Source |
---|
Sci Rep
December 2024
Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0374, Kanagawa, Japan.
To investigate the functional role of S100A4 in advanced colorectal carcinoma (Ad-CRC) and locally advanced rectal carcinoma (LAd-RC) receiving neoadjuvant chemoradiotherapy (NCRT). We analyzed histopathological and immunohistochemical sections from 150 patients with Ad-CRC and 177 LAd-RC patients treated with NCRT. S100A4 knockout (KO) HCT116 cells were also used.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Accidental bending of the snare sheath occasionally occurs during cold snare polypectomy (CSP). We aimed to demonstrate whether snare bending reduces resection ability and, if it does, what causes this reduction. Using currently available CSP snares and prototype snares, we investigated changes in the resection ability of bent snares as well as the stiffness of their sheaths and wire spindles.
View Article and Find Full Text PDFADMET DMPK
October 2024
PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur-209305, U.P., India.
Background And Purpose: The study explores basil seed mucilage as a bioadhesive carrier for naproxen sodium, demonstrating its ability to enhance solubility when administered rectally. The mucilage, derived from seeds, showed bioadhesive properties and thermal stability, as confirmed by FTIR spectroscopy and X-ray diffraction analysis.
Experimental Approach: Microspheres were prepared using a double emulsion solvent evaporation technique, varying polymer ratios to optimize drug delivery.
Tech Coloproctol
December 2024
Department of Epidemiology, Deventer Hospital, Schalkhaar, The Netherlands.
Background And Study Aim: Local resection of early rectal cancer is being increasingly used. With invasion of the muscularis propria layer of the rectal wall, the risk of lymph node metastasis becomes too high to consider this the optimal oncological treatment. Therefore, a diagnosis of muscular invasion is important before attempting local resection; however, endoscopic and magnetic resonance imaging (MRI) images have limitations, such as overstaging (26-31%).
View Article and Find Full Text PDFNeurogastroenterol Motil
December 2024
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Background: Irritable bowel syndrome (IBS) is a common functional gastro-intestinal disorder characterized by discomfort with constipation and/or diarrhea with unclear pathophysiology. We aimed to determine the activities of colorectal eosinophils, neutrophils and epithelial cells by biomarkers in feces reflecting these activities.
Methods: Fecal samples were collected from 185 patients with IBS before and after 8 weeks of placebo or mesalazine treatment and from 40 healthy subjects.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!