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Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children.
Cochrane Database Syst Rev
November 2024
Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Background: About 80% of children with steroid-sensitive nephrotic syndrome (SSNS) have relapses. Of these children, half will relapse frequently, and are at risk of adverse effects from corticosteroids. While non-corticosteroid immunosuppressive medications prolong periods of remission, they have significant potential adverse effects.
View Article and Find Full Text PDFMinimally invasive liver resection for cholangiolocellular carcinoma: A single-institution experience.
Asian J Endosc Surg
January 2024
Department of Surgery, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
Article Synopsis
- Cholangiolocellular carcinoma (CoCC) is often misdiagnosed due to its similarities with cholangiocellular carcinoma (CCC), making preoperative identification challenging.
- A study of 15 CoCC patients treated with either laparoscopic liver resection (LLR) or open liver resection (OLR) showed varying outcomes, with a significant number achieving good 5-year disease-free and overall survival rates.
- The study suggests that minimally invasive liver resection is a safe and effective treatment option for CoCC, but further research is required to validate these findings.
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use.
Parasit Vectors
October 2023
UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (WHO/TDR), World Health Organization, Geneva, Switzerland.
Article Synopsis
- The World Health Organization (WHO) laid out its objectives for controlling and eliminating neglected tropical diseases (NTDs) in a 2021-2030 roadmap, emphasizing the need for new treatment options and research.
- A review of current anti-infective drug developments reveals that the existing pipeline cannot meet all treatment needs for NTDs, and WHO allows for off-label drug use based on safety and efficacy.
- The article summarizes the lack of clinical research over the past decade on oral small-molecule drugs for numerous NTDs that are neither approved by regulatory authorities nor included in WHO strategies, identifying specific diseases and drugs that have not been thoroughly evaluated.
Efficacy of a fixed-dose combination injectable (0.2 mg/kg doramectin + 6.0 mg/kg levamisole hydrochloride) in New Zealand cattle against naturally acquired gastrointestinal nematode populations with demonstrated resistance to doramectin.
Vet Parasitol
November 2023
Zoetis, Veterinary Medicine Research and Development, 333 Portage St, Kalamazoo, MI 49007, USA. Electronic address:
Intensive farming practices and heavy reliance on anthelmintics have contributed significantly to the problem of macrocyclic lactone (ML) resistance in New Zealand. Farmers now have few options for effectively controlling cattle gastrointestinal nematodes (GINs) and regularly experience sub-optimal efficacy against economically important species. We present a novel fixed-dose combination injectable (FDCI) that simultaneously delivers 0.
View Article and Find Full Text PDFDistress in parents of children with first-onset steroid-sensitive nephrotic syndrome.
Pediatr Nephrol
December 2023
Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam University Medical Centers, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Background: Steroid-sensitive nephrotic syndrome (SSNS) is associated with a relapsing-remitting course that can be stressful for parents. As little is known of parental distress at the first onset of SSNS, this study aims to describe parental distress and everyday problems in mothers and fathers of a child with newly diagnosed SSNS participating in a randomized controlled trial of levamisole added to corticosteroids.
Methods: To assess distress, the Distress Thermometer for Parents (DT-P) was used, which includes questions on distress (thermometer score 0-10, ≥ 4 "clinical distress") and presence of everyday problems in six domains: practical, social, emotional, physical, cognitive, and parenting.
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