The subtile comprehension of the proteinuria is applied to an early recognition of the diabetic microangiopathia in the sphere of the kidneys. A series of usual methods of the determination of urine protein is compared with different protein clearance results. From these examinations follows that qualitative determinations of protein are unsuitable and quantitative investigations of protein show only an orienting character for the estimation of a microangiopathia. The determination of proteins in urine selectively and non-selectively secreted shows direct relations to microangiopathia and thus could also be applied to the estimation of disturbances in microcirculations in the sphere of physiological proteinuria.
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