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Evidence for in vivo resistance against allopurinol in a dog infected with Leishmania infantum by reduction in copy numbers of the S-adenosylmethionine synthetase (METK) gene.
Parasit Vectors
December 2024
Koret School of Veterinary Medicine, The Hebrew University, Rehovot, Israel.
Background: In Europe, canine leishmaniasis is commonly caused by Leishmania infantum. Allopurinol is the main drug for long-term management of the disease, and clinical relapses of L. infantum infection treated with this drug are described.
View Article and Find Full Text PDFMetabolism of inorganic arsenic in mice carrying the human AS3MT gene and fed folate deficient or folate supplemented diet.
Toxicol Appl Pharmacol
November 2024
Department of Nutrition, CB# 7461, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA. Electronic address:
Arsenic (+3 oxidation state) methyltransferase (AS3MT) catalyzes the S-adenosylmethionine (SAM)-dependent methylation of inorganic arsenic (iAs), yielding monomethyl‑arsenic (MAs) and dimethyl‑arsenic (DMAs) metabolites. The formation of DMAs in this pathway is considered a key mechanism for iAs detoxification. Availability of SAM for iAs methylation depends in part on dietary intake of folate.
View Article and Find Full Text PDF[Guidelines for diagnosis and management of drug-induced liver injury caused by anti-tuberculosis drugs (2024 version)].
Zhonghua Jie He He Hu Xi Za Zhi
November 2024
Article Synopsis
- Drug-induced liver injury (DILI), specifically anti-tuberculosis drug-induced liver injury (ATB-DILI), is a common side effect of tuberculosis treatment, prompting the Chinese Medical Association Tuberculosis Branch to create guidelines for better diagnosis and management.
- These guidelines cover various topics, including risk factors (such as genetic variations and existing liver conditions), clinical classification, and comprehensive diagnostic procedures like blood tests and imaging.
- Key recommendations include assessing liver function through specific biochemical tests, collecting detailed medical histories, and using liver biopsies for accurate diagnosis and prognosis of ATB-DILI.
Differential One-Carbon Metabolites among Children with Autism Spectrum Disorder: A Case-Control Study.
J Nutr
November 2024
Department of Neurological Rehabilitation, Guizhou Branch of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Guiyang, China; Department of Rehabilitation, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. Electronic address:
Article Synopsis
- - The study investigates the link between folate-dependent one-carbon metabolism (OCM) and autism spectrum disorder (ASD) by comparing plasma OCM metabolites in children with ASD to neurotypical children.
- - Results show significant differences in ten out of twenty-two metabolites, with higher levels of S-adenosylmethionine (SAM) and lower levels of S-adenosylhomocysteine (SAH) and other metabolites in children with ASD.
- - The findings suggest disturbances in methionine methylation and trans-sulfuration pathways in children with ASD, indicating potential for targeting OCM as a therapeutic avenue for ASD.
Exposure to prenatal excess or imbalanced micronutrients leads to long-term perturbations in one-carbon metabolism, trimethylamine-N-oxide and DNA methylation in Wistar rat offspring.
FASEB J
August 2024
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Prenatal multivitamins, including folic acid, are commonly consumed in excess, whereas choline, an essential nutrient and an important source of labile methyl groups, is underconsumed. Here, we characterized profiles of one-carbon metabolism and related pathways and patterns of DNA methylation in offspring exposed to excess or imbalanced micronutrients prenatally. Pregnant Wistar rats were fed either recommended 1× vitamins (RV), high 10× vitamins (HV), high 10× folic acid with recommended choline (HFolRC), or high 10× folic acid with no choline (HFolNC).
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