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Transmenopausal changes in cortical bone quality.
Bone
October 2024
Osteoporosis Research Center, Creighton University, Omaha, NE, USA.
Bone's resistance to fracture depends on its amount and quality, the latter including its structural and material/compositional properties. Bone material properties are dependent on bone turnover rates, which are significantly elevated immediately following menopause. Previously published data reported that following menopause, the amount of organic matrix synthesized at actively forming surfaces is significantly decreased, while glycosaminoglycan content was also modulated at resorbing surfaces, in the cancellous compartment.
View Article and Find Full Text PDFEffect of Tempeh and Daidzein on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in Ovariectomized Rats.
Nutrients
February 2024
Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60-624 Poznan, Poland.
Article Synopsis
- Menopause leads to hormonal changes that negatively affect bone health, increasing the risk of fractures, prompting research on the effects of daidzein and tempeh on calcium and bone metabolism in ovariectomized rats.
- In a two-phase experiment with 40 female Wistar rats, dietary interventions were tested in five groups, revealing that the tempeh group significantly increased bone turnover markers compared to others.
- Histological results showed that both daidzein and tempeh functions similarly to bisphosphonates, suggesting that these isoflavones may enhance calcium status and bone metabolism, possibly due to their estrogen-like properties.
Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications.
Reprod Sci
March 2024
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Collagen is an essential constituent of the uterine extracellular matrix that provides biomechanical strength, resilience, structural integrity, and the tensile properties necessary for the normal functioning of the uterus. Cross-linking is a fundamental step in collagen biosynthesis and is critical for its normal biophysical properties. This step occurs enzymatically via lysyl oxidase (LOX) or non-enzymatically with the production of advanced glycation end-products (AGEs).
View Article and Find Full Text PDFTissue anisotropy and collagenomics in porcine penile tunica albuginea: Implications for penile structure-function relationships and tissue engineering.
Acta Biomater
October 2023
Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Electronic address:
The tunica albuginea (TA) of the penis is an elastic layer that serves a structural role in penile erection. Disorders affecting the TA cause pain, deformity, and erectile dysfunction. There is a substantial clinical need for engineered replacements of TA, but data are scarce on the material properties and biochemical composition of healthy TA.
View Article and Find Full Text PDFHuman nasal cartilage: Functional properties and structure-function relationships for the development of tissue engineering design criteria.
Acta Biomater
September 2023
Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697, USA. Electronic address:
Nose reconstruction often requires scarce cartilage grafts. Nasal cartilage properties must be determined to serve as design criteria for engineering grafts. Thus, mechanical and biochemical properties were obtained in multiple locations of human nasal septum, upper lateral cartilage (ULC), and lower lateral cartilage (LLC).
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