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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation.
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Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Delayed radiation-induced brain injury (RIBI) characterized by progressive cognitive decline significantly impacts patient outcomes after radiotherapy. The activation of NLRP3 inflammasome within microglia after brain radiation is involved in the progression of RIBI by mediating inflammatory responses. We have previously shown that sulfonylurea receptor 1-transient receptor potential M4 (SUR1-TRPM4) mediates microglial NLRP3-related inflammation following global brain ischemia.
View Article and Find Full Text PDFPain Perception Threshold in Young High-Altitude Natives After Acute Exposure to Severe Hypoxic Conditions.
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Centro de Investigación en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima 15001, Peru.
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Department of Cardiology, West China Hospital, Sichuan University West China School of Medicine, 37 Guoxue Road, Chengdu, Sichuan, 610041, China.
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View Article and Find Full Text PDFSystematic Review and Meta-Analysis to Assess Safety and Early Mortality in Octogenarians undergoing Fenestrated and Branched Endovascular Aortic Repair for Complex Aortic Aneurysms.
Ann Vasc Surg
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Division of Vascular Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA.
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View Article and Find Full Text PDFand Extracts Mixture Target Pyroptosis in Ischemic Stroke via the NLRP3 Pathway.
Int J Mol Sci
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Department of Health Sciences and Technology, Gachon Advanced Institute for Health Science & Technology, Gachon University, Incheon 21999, Republic of Korea.
Ischemic stroke, caused by blocked cerebral blood flow, requires prompt intervention to prevent severe motor and cognitive impairments. Despite extensive drug development efforts, the failure rate of clinical trials remains high, highlighting the need for novel therapeutic approaches. This study investigated the therapeutic potential of a natural herbal extract mixture of Bunge (AM) and Georgi (SB), traditionally used in Eastern Asian herbal medicine (EAHM) for ischemic stroke treatment.
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