A totally artificial heart--the Rostock totally artificial heart (Rostock TAH) was implanted in calves. We can give the following deductions after 27 examinations: -- The Rostock TAH was tested successfully in endurance test about 7 months; it show no sign of wear. -- The surgical technique of the implantation was standardised and a successful experimentation is possible. -- The longest survival time was 15 days. The hemodynamic early results were very good in 3 other animals. -- Modifications of the Rostock TAH were taken up relating to the dimensions of the artificial ventriculi and by mounting a screw cap for avoiding an air embolism. -- Adaption tests in the corpse show that the present form of the artificial heart is not ideal for a possible application in man. -- The problem is still existing in developing a suitable drive system locates intrathoracically. The present drive and control system on a pneumatic base is qualified only for the animal experiment but not for a possible application in man.
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Pathophysiology
May 2003
CFDR, St. Anna University Hospital, Pekarská 53, 656 91, Brno, Czech Republic
Implanted biomaterials are often inevitably attacked by the bacterial infection. So far this problem has not been sufficiently explained and solved. It represents an 'evergreen' in the artificial heart research.
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December 2000
VACORD Bioengineering Research Company, Brno, Czech Republic.
Electronmicroscopic (EM) evaluation of selected vital organs (liver, kidney, lung) informs us about otherwise hardly detectable changes during total artificial heart (TAH) pumping. In our experiments, we compared 2 groups of long-surviving animals in which the TAH TNS-BRNO pneumatic device was implanted (TNS-BRNO-II and VII in 45 experiments, TNS-BRNO-III in 1 experiment, and TNS-BRNO-VIII in 1 experiment). In 4 experiments, the Rostock TAH (NABEL, TAH Research Center, Rostock, Germany) was implanted.
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June 1995
Vacord Bioengineering Research Company, Brno, Czech Republic.
Twelve total artificial heart (TAH) models have been developed at the Brno Research Center. Devices VII, VIII, and IX were constructed on the principle of asymmetry. Three main objectives had to be fulfilled by this construction.
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January 1990
Clinic for Internal Medicine, Wilhelm-Pieck-University Rostock, German Democratic Republic.
Right/left matching in the total artificial heart (TAH) is essential to prevent fatal volume displacement into the pulmonary circuit. Measurements were made with three different sized Rostock pneumatic artificial ventricles incorporated in the Donovan mock circulatory system together with the heart driver AKT 86. First for each ventricle we determined the dependence of the maximum effective stroke volume on the systolic driving pressure and the afterload.
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March 1990
Institute of Pathophysiology, Faculty of Medicine, Purkynĕ University, CSSR.
The authors present basic information about the technical development of the total artificial heart (TAH) and TAH drivers. Long-term experiments, in which the TAH TNS-Brno-II and VII and the Rostock hearts were implanted, are described. Long-term experiments were dedicated to analysis of specific pathophysiologic problems (venous hypertension, thrombogenesis, and calcification) in order to increase survival rates.
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