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Circulating proteomic profiles are associated with type 2 diabetes in Asian populations - a longitudinal study.
J Clin Endocrinol Metab
January 2025
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Context: Type 2 diabetes (T2D) is a major global concern, with Asia at its epicenter in recent years. Proteins, products of gene transcription, serve as dynamic biomarkers for pinpointing perturbed pathways in disease development. Previous T2D proteomic association studies primarily focused on European populations.
View Article and Find Full Text PDFThe Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis.
J Cosmet Dermatol
January 2025
Department of Dermatology, Sichuan Huamei Zixin Medical Aesthetic Hospital, Chengdu, Sichuan, China.
Background: Aging reduces the production of hyaluronic acid (HA) in the skin, leading to wrinkles and sagging. HA-based skincare products are being studied to improve skin quality. This systematic review and meta-analysis aimed to compare the effectiveness of HA-based injectable products for reducing wrinkles and enhancing skin elasticity, hydration, and radiation.
View Article and Find Full Text PDFSimple and Smart Metal-Phenolic Micelles for Optimizing Immunotherapy by Disrupting Tumor Stemness.
Nano Lett
January 2025
School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China.
cGAS-STING pathway activation has attracted considerable attention in antitumor immunotherapy, but clinical outcomes lag behind expectations due to overlooked negative feedback mechanisms. Here, we determine that STING activation promotes tumor stemness, which weakens the efficacy of STING-based therapies, presenting a double-edged sword. To address this therapeutic paradox, a simple metal-phenolic polymeric micelle (HMQ) was developed, in which Mn (a STING agonist) is coordinated with quercetin (a stemness inhibitor) and hyaluronic acid (HA), to unlock the full therapeutic potential of the cGAS-STING pathway.
View Article and Find Full Text PDFThe Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin-A Randomized, Controlled, Crossover Study.
Clin Transl Sci
January 2025
Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Exercise increases blood and lymph flow in working muscles, potentially affecting the bioavailability and effect of subcutaneously administered drugs. The aim of this study was to assess the influence of a single exercise session on pharmacokinetics and pharmacodynamics of a single dose of subcutaneously administered unfractionated heparin. In a crossover design, 15 healthy males underwent four experimental days where 15,000 IU of unfractionated heparin was injected subcutaneously into the thigh of the non-dominant leg.
View Article and Find Full Text PDFChondroitin Sulfate and Proteinoids in Neuron Models.
ACS Appl Bio Mater
January 2025
Unconventional Computing Laboratory, University of the West of England, Bristol BS16 1QY, U.K.
This study examines the relationship between chondroitin sulfate, proteinoids, and computational neuron models, with a specific emphasis on the Izhikevich neuron model. We investigate the effect of chondroitin sulfate-proteinoid complexes on the behavior and dynamics of simulated neurons. Through the use of computational simulations, we provide evidence that these biomolecular components have the power to regulate the responsiveness of neurons, the patterns of their firing, and the ability of their synapses to change within the Izhikevich architecture.
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