A case of dermatofibrosarcoma protuberans is presented where radiotherapy had been part of the management of multiple recurrent lesions. Over a course of 46 years, complete response occurred in 2 out of 3 lesions after medium-and high-dose radiation therapy and in 1 out of 5 lesions after interstitial therapy. Regression of the lesions took several months. In the literature, 5 additional cases of local control and 2 of partial control after high-dose radiotherapy are reported. When failure of radiotherapy was reported, the dose had been low and the observation time short in many cases. High-dose radiotherapy used with patience might be tried in selected cases.
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