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Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes.
Commun Biol
November 2024
Department of Zoology & Developmental Biology, University of Osnabrück, 49076, Osnabrück, Germany.
Drosophila nephrocytes are specialised cells that share critical functional, morphological, and molecular features with mammalian podocytes. Accordingly, nephrocytes represent a preferred invertebrate model for human glomerular disease. Here, we established a method for cell-specific isolation of the two types of Drosophila nephrocytes, garland and pericardial cells, from animals of different developmental stages and ages.
View Article and Find Full Text PDFIn Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation.
Pharmaceutics
January 2024
Institute of Integrated Clinical Practice and Laboratory of Evidence-Based and Precision Dentistry, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal.
Reversine is a purine derivative that has been investigated with regard to its biological effects, such as its anticancer properties and, mostly, its ability to induce the dedifferentiation of adult cells, increasing their plasticity. The obtained dedifferentiated cells have a high potential for use in regenerative procedures, such as regenerative dentistry (RD). Instead of replacing the lost or damaged oral tissues with synthetic materials, RD uses stem cells combined with matrices and an appropriate microenvironment to achieve tissue regeneration.
View Article and Find Full Text PDFA unique cell population expressing the Epithelial-Mesenchymal Transition-transcription factor Snail moderates microglial and astrocyte injury responses.
PNAS Nexus
October 2023
Department of Anatomy and Cell Biology, School of Medicine and Health Sciences, George Washington University, 2300 Eye Street NW, Ross 735, Washington, DC 20052, USA.
Insults to the central nervous system (CNS) elicit common glial responses including microglial activation evidenced by functional, morphological, and phenotypic changes, as well as astrocyte reactions including hypertrophy, altered process orientation, and changes in gene expression and function. However, the cellular and molecular mechanisms that initiate and modulate such glial response are less well-defined. Here we show that an adult cortical lesion generates a population of ultrastructurally unique microglial-like cells that express Epithelial-Mesenchymal Transcription factors including Snail.
View Article and Find Full Text PDFModifications of native lotus (Nelumbo nucifera G.) rhizome starch and its overall characterization: A review.
Int J Biol Macromol
December 2023
Department of Botany, Chaudhary Devi Lal University, Sirsa, Haryana 125055, India.
Lotus (Nelumbo nucifera G.) rhizomes are an under-utilized and sustainable starch source that constitutes up to 20 % starch. The review mainly focused on the extraction methods of starch, the chemical composition of LRS, and techno-functional characteristics such as swelling power, solubility, in vitro digestibility, pasting property, and gelatinization is highlighted in LRS review.
View Article and Find Full Text PDFTrunk muscles' characteristics in adolescent gymnasts with low back pain: a pilot study on the effects of a physiotherapy intervention including a postural reeducation program.
J Man Manip Ther
June 2024
School of Physiotherapy, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Article Synopsis
- The study investigates the trunk muscles of young gymnasts, focusing on their function, structure, and contractility, particularly in relation to chronic low back pain (LBP).
- The research found that LBP correlates with an imbalanced endurance ratio between flexor and extensor muscles, decreased lumbar multifidus thickness, and reduced displacement in the erector spinae.
- A physiotherapy intervention improved LBP symptoms and positively affected the muscle endurance ratio, highlighting the potential benefits of targeted rehabilitation for young athletes.
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