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Neurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology.
Brain Res Bull
January 2025
Graduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Research Institute of Disaster Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Health and Disease Omics Center, Chiba University, Chiba, Japan. Electronic address:
Ischemic stroke (IS) is a pathological condition characterized by the cessation of blood flow due to factors such as thrombosis, inflicting severe damage to the cranial nervous system and resulting in numerous disabilities including memory impairments and hemiplegia. Despite the critical nature of this condition, therapeutic options remain limited, with a pressing challenge being the development of treatments aimed at restoring neurological function. In this study, we leveraged zebrafish, renowned for their exceptional regenerative capabilities, to analyze the pathology of IS and the subsequent recovery process.
View Article and Find Full Text PDFPC-CS-YOLO: High-Precision Obstacle Detection for Visually Impaired Safety.
Sensors (Basel)
January 2025
Engineering Training Center, Nantong University, Nantong 226019, China.
The issue of obstacle avoidance and safety for visually impaired individuals has been a major topic of research. However, complex street environments still pose significant challenges for blind obstacle detection systems. Existing solutions often fail to provide real-time, accurate obstacle avoidance decisions.
View Article and Find Full Text PDFA Synergy of Convolutional Neural Networks for Sensor-Based EEG Brain-Computer Interfaces to Enhance Motor Imagery Classification.
Sensors (Basel)
January 2025
Department of Mechanical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia.
Enhancing motor disability assessment and its imagery classification is a significant concern in contemporary medical practice, necessitating reliable solutions to improve patient outcomes. One promising avenue is the use of brain-computer interfaces (BCIs), which establish a direct communication pathway between users and machines. This technology holds the potential to revolutionize human-machine interaction, especially for individuals diagnosed with motor disabilities.
View Article and Find Full Text PDFNeurobehavioral Outcomes Relate to Activation Ratio in Female Carriers of Fragile X Syndrome Full Mutation: Two Pediatric Case Studies.
Int J Mol Sci
January 2025
Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder that causes a range of developmental problems including cognitive and behavioral impairment and learning disabilities. FXS is caused by full mutations (FM) of the gene expansions to over 200 repeats, with hypermethylation of the cytosine-guanine-guanine (CGG) tandem repeated region in its promoter, resulting in transcriptional silencing and loss of gene function. Female carriers of FM are typically less impaired than males.
View Article and Find Full Text PDFThe Meaning of Ageing and the Educational Intervention "Good Life in Old Age": An Ethnographic Study Reflecting the Perspective of Older Adults with Mild Intellectual Disability.
Int J Environ Res Public Health
January 2025
Department of Health Sciences, Faculty of Medicine, Lund University, P.O. Box 117, SE-221 00 Lund, Sweden.
Older adults with intellectual disabilities are not adequately prepared for ageing and show anxiety and uncertainty regarding the future. Therefore, the two-year educational intervention "Good Life in Old Age" was implemented to improve their understanding of ageing and enhance their well-being. This study aimed to explore the meaning of ageing during and after the intervention from the perspective of older adults with mild intellectual disability.
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