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Restoration of disc height and biomechanical function is essential for intervertebral disc degeneration (IDD) treatment. Removing abnormal nucleus pulposus (NP) tissue is an important step to facilitate bony fusion during the healing process. We analyzed publicly available single-cell transcriptome data for human normal and degenerative NP to identify genes associated with NP degeneration.

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Article Synopsis
  • Nano-engineering in dentistry has improved dental implants through advanced surface modifications, enhancing bone cell interaction and osseointegration.
  • The study involved modifying zirconia implants with allylamine and fibronectin nanoproteins, tested on rabbits over 12 weeks for stability and bone integration.
  • Results showed significant stability and new bone formation in treated implants, indicating that nanoparticle modifications effectively boost dental implant performance.
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Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis.

Nat Commun

November 2024

Buchmann Institute for Molecular Life Sciences (BMLS), Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 15, D-60438, Frankfurt am Main, Germany.

Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover the role of the angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous system (CNS) vascular development in the mouse. Early postnatal FLRT2 deletion reveals specific defects in retinal veins, impacting endothelial cell proliferation, sprouting and polarity that result in reduced tip cells at the vascular front.

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Article Synopsis
  • - The study compares two decellularization methods (enzyme-detergent and detergent-detergent) to see how they affect the structure and mechanics of human urethral tissue, using samples from 18 individuals.
  • - Both methods successfully removed cellular content while maintaining essential extracellular matrix components like collagen and elastic fibers, indicating they preserved the tissue's structural integrity.
  • - Biomechanical tests showed that the detergent-detergent method resulted in lower stress levels compared to native tissues, and both methods had reduced elasticity, but none were toxic to stem cells, suggesting they are viable for tissue engineering and biobanking.
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Background: Hyalocytes are the main vitreal cell types with critical functions in health and vitreoretinal diseases. Our aim was to develop cultures of human hyalocytes and verify the retention of their initial cellular features after 3 and 6 days of culturing (3 d and 6 d) by analyzing and comparing a few morphological and functional parameters.

Methods: Vitreous samples (n = 22) were collected and vitreous cells and bead-enriched hyalocytes were developed and compared (3 d vs.

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