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Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection.
Front Immunol
October 2024
Centre for Experimental Pathogen Host Research (CEPHR), University College Dublin, Dublin, Ireland.
Introduction: A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine and relationship to incident SARS-CoV-2 infection.
Methods: Adults in a prospective cohort provided blood samples at day 0, day 14, and 10 months after the third-dose SARS-CoV-2 vaccine.
Lessons learnt from the first two SARS-CoV-2 Omicron waves of the COVID-19 pandemic in six remote Aboriginal and Torres Strait Islander communities in Queensland, Australia: a retrospective epidemiological review.
Med J Aust
October 2024
Queensland Health, Brisbane, QLD.
Article Synopsis
- The study evaluated the preparedness for and public health responses to the first two COVID-19 waves in six remote Aboriginal and Torres Strait Islander communities in Queensland.
- Vaccination coverage varied before the first outbreak, with first doses ranging from 59% to 84% and second doses from 39% to 76%.
- During the study, 2,624 COVID-19 cases were reported, with attack rates differing across communities and only a small number resulting in hospitalization or death.
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Ann Intern Med
September 2024
Departments of Pediatrics and Medicine, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, Ohio (G.A.M.).
Article Synopsis
- The study aims to identify clinical laboratory markers associated with postacute sequelae of SARS-CoV-2 infection (PASC) due to a lack of validated biomarkers.
- Conducted with 10,094 participants across 83 sites, the research compared laboratory measures between those with and without prior SARS-CoV-2 infection and analyzed the impact of PASC indices on these measures.
- Results showed participants with prior infection had lower platelet counts and higher levels of hemoglobin A and urinary albumin-creatinine ratio, but these differences were minor and not significant among those with PASC.
Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
PLoS One
June 2023
Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Article Synopsis
- SARS-CoV-2 infection can lead to long-term health issues known as post-acute sequelae of SARS-CoV-2 infection (PASC) or long COVID, which can manifest as ongoing or new symptoms after the initial infection.
- The RECOVER-Adult study aims to better understand PASC by investigating its prevalence, symptoms, risk factors, and underlying biological mechanisms through a large cohort of nearly 15,000 adults.
- Participants will provide ongoing data through questionnaires, physical examinations, and biological samples over several months, helping researchers gather critical insights into the complexities of long COVID.
Importance: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.
Objective: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.
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