AI Article Synopsis
- Research on Aplysia neurons reveals that prolonged inhibition from cholinergic and dopaminergic signals blocks the inward current essential for slow oscillations during burst firing.
- This inhibition mirrors the effects of temperature and ionic conditions on the inward current, demonstrating a strong relationship between these factors.
- The prolonged inhibition is irreversible and unaffected by changes in extracellular potassium levels, indicating that it stems from a synaptic mechanism that inactivates the slow inward current responsible for bursting behavior.
Article Abstract
By using voltage clamping and microiontophoretic techniques, it has been found that the prolonged cholinergic and dopaminergic inhibition seen in Aplysia burst firing neurons occludes the inward current on which slow oscillations depend. It also mimics the temperature and ionic sensitivity of that inward current. This prolonged inhibition, which cannot be inverted and is insensitive to extracellular potassium changes, thus appears to result from a synaptically produced inactivation of the regenerative slow inward current underlying bursting.
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| http://dx.doi.org/10.1126/science.715442 | DOI Listing |
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