A blind volunteer was inoculated in one eye with an isolate of Chlamydia trachomatis in 1961 and followed for 20 years. During this time, many observations were made of his clinical responses to the first inoculation and several subsequent inoculations with the same and other strains, chlamydial shedding, and antibody and cell-mediated immune responses. Evidence is presented that partial resistance to chlamydial eye infection developed during repeated infections and that antibodies, cell-mediated immune reactions, and specific antigen in conjunctival cells persisted for many years after the last infection. The antibody response was directed mainly against the original infecting immunotype, regardless of whether the response was restimulated by infection with the same immunotype or with other immunotypes. The lymphocyte stimulation response appeared to be species specific.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC272499PMC
http://dx.doi.org/10.1128/jcm.16.5.895-900.1982DOI Listing

Publication Analysis

Top Keywords

chlamydia trachomatis
8
cell-mediated immune
8
long-term clinical
4
clinical microbiological
4
microbiological immunological
4
immunological observations
4
observations volunteer
4
volunteer repeatedly
4
repeatedly infected
4
infected chlamydia
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!