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The Safety Profile of Amiodarone Among Older Adults (age ≥ 75 years): A Pharmacovigilance Study from the FDA Data.
Am J Med
January 2025
The Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sheba Medical Center, Ramat-Gan, Israel; Division of Geriatric Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:
Background: Amiodarone is a widely used antiarrhythmic agent with significant toxicities and drug interactions more likely to affect older adults. Nevertheless, data regarding amiodarone safety in this population are limited.
Methods: We conducted a retrospective analysis of FDA Adverse Event Reporting System (FAERS) data from 2003 to 2024 .
Development of new K2.1 channel openers from propafenone analogues.
Br J Pharmacol
February 2025
Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Article Synopsis
- Reduced functioning of the K2.1 potassium channel is linked to conditions like heart failure and Andersen-Tawil Syndrome, making it crucial to find treatments that specifically target this channel, as current therapies do not.
- Research analyzed the effects of propafenone and its analogues on the K2.1 channel using techniques like patch-clamp electrophysiology and western blot analysis, highlighting the potential of these compounds to improve potassium current.
- Notably, the analogue GPV0057 increased the potassium current without blocking it at low concentrations, suggesting it could be a viable treatment option for diseases related to K2.1 deficiency.
Evaluation of Amiodarone Administration in Patients with New-Onset Atrial Fibrillation in Septic Shock.
Medicina (Kaunas)
September 2024
Dental-Medicine Department, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, 800008 Galati, Romania.
: New-onset atrial fibrillation (NOAF) is a common cardiac condition often observed in intensive care units. When amiodarone is used to treat this condition, either to maintain sinus rhythm after electrical cardioversion or to control heart rate, complications can arise when a systemic pathology is present. Systemic pathology can result in a decrease in cardiac output and blood pressure, making the management of NOAF and septic shock challenging.
View Article and Find Full Text PDFEffect of Obesity on the Use of Antiarrhythmics in Adults With Atrial Fibrillation: A Narrative Review.
Clin Cardiol
August 2024
Centre for Chronic & Complex Care Research, Blacktown Hospital, Western Sydney Local Health District, Blacktown, New South Wales, Australia.
Background: Atrial fibrillation (AF) and obesity coexist in approximately 37.6 million and 650 million people globally, respectively. The anatomical and physiological changes in individuals with obesity may influence the pharmacokinetic properties of drugs.
View Article and Find Full Text PDFFactors influencing early recurrence of atrial fibrillation among elderly patients following radiofrequency catheter ablation and the impact of different antiarrhythmic regimens.
Front Med (Lausanne)
June 2024
Department of Emergency, The 967th Hospital of Joint Logistics Support Force of Chinese PLA, Dalian, China.
Background: Patients with atrial fibrillation (AF) who undergo radiofrequency catheter ablation (RFCA) necessitate the administration of antiarrhythmic drugs to prevent early recurrence. The clinical outcomes among these patients may be influenced by varying antiarrhythmic regimens.
Objectives: To identify the risk factors associated with early recurrence and compare the clinical outcomes among different antiarrhythmic regimens in elderly patients with AF following radiofrequency catheter ablation (RFCA) during a 3-month period.
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