This is a cohort study of the mortality among chimney sweeps in Copenhagen, Denmark, during 1958-77. Nearly all the chimney sweeps started in the trade around the age of 15, and so this age gives the time of first exposure to the environmental conditions of the trade. The analysis applies a continuous time model with stratification by cause of death (cancer, non-cancer), time and age, where cumulative mortality rates are derived from current mortality tables. For each stratum of interest the observed/expected mortality ratio (O/E ratio) is calculated and a test performed, based on the normal distribution. The main result is a significantly higher cancer mortality for the 40-69 year age class compared with the population at large (O/E ratio = 3.9).
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http://dx.doi.org/10.1093/ije/11.4.356 | DOI Listing |
Front Epidemiol
September 2024
Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Traditional methods for measuring chemical exposure have challenges in terms of obtaining sufficient data; therefore, improved methods for better assessing occupational exposure are needed. One possible approach to mitigate these challenges is to use self-monitoring methods such as sensors, diaries, or biomarkers. In the present study, a self-monitored method for measuring soot exposure, which included real-time air monitoring, a work diary, and the collection of urine samples, was evaluated.
View Article and Find Full Text PDFJ Occup Environ Hyg
January 2024
Department of Occupational and Environmental Medicine, University Hospital of North Norway (UiT), Tromsø, Norway.
Exposure to polycyclic aromatic hydrocarbons (PAHs) of high molecular weight from chimney soot can cause cancer among chimney sweepers. These sweepers may also be exposed to high concentrations of nanosized particles, which can cause significant inflammatory responses due to their relatively greater surface area per mass. In this study, the authors aimed to assess the exposure profiles of airborne personal exposure to gaseous and particulate PAHs, and real-time samples of the particle number concentrations (PNCs), particle sizes, and lung-deposited surface areas (LDSAs), for chimney sweepers in Norway.
View Article and Find Full Text PDFClin Dermatol
June 2022
Department of Pathology, Hospital de La Reina, Ponferrada, Spain; Department of Dermatology, Hospital Universitario de A Coruña, A Coruña, Spain.
The 18th century was linked to a type of skin cancer with a clear professional etiology: scrotal carcinoma in chimney sweeps. Sir Percival Pott had the merit of identifying the disease as a malignant and inexorable process and of describing its natural evolution. In this article, we present some historical aspects of such description, as well as the working environment of the main individuals affected by this cancer, who were children carrying out the work of chimney sweeps.
View Article and Find Full Text PDFRev Neurol (Paris)
September 2022
Cabinet privé, 40, rue d'Alleray, 75015 Paris, France.
Physicians remember the name of the surgeon Percivall Pott (1713-1788) because of the eponym "Pott's disease", described as "paralysis in the lower limbs, which is often accompanied by curvature of the spine". Pott's writings on surgical subjects are far vaster. For example, he described the fracture-dislocation of the ankle, or Pott's fracture, and determined the cause of scrotum cancer in chimney sweeps.
View Article and Find Full Text PDFCold Spring Harb Perspect Med
March 2021
Department of Pathology, Genetics, and Biology, Stanford University, Stanford, California 94305-5324, USA
Observations of the incidence of tumors among chimney sweeps in the eighteenth century and later experiments with coal tars provided early evidence that carcinogens in the environment can promote cancer. Subsequent studies of individuals exposed to radiation, work on fly genetics, and the discovery that DNA was the genetic material led to the idea that these carcinogens act by inducing mutations in DNA that change the behavior of cells and ultimately cause cancer. In this excerpt from his forthcoming book, Joe Lipsick looks back at how the concepts of mutagenesis and carcinogenesis emerged, how these converged with development of the Ames test, and how biochemistry and crystallography ultimately revealed the underlying molecular basis.
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