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Oral Esketamine as Alternative for Maintenance Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Case Series.
J ECT
January 2025
From the Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Objectives: This study investigates repeated oral esketamine as a substitution strategy for maintenance electroconvulsive therapy (M-ECT) in eight patients with treatment-resistant depression (TRD).
Methods: In a 6-week dosing phase, esketamine was titrated from 0.5 or 1.
Trajectory of peripheral inflammation during index ECT in association with clinical outcomes in treatment-resistant depression.
Brain Behav Immun Health
February 2025
Department of Psychiatry & Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Background: Electroconvulsive therapy (ECT) is a highly efficacious intervention for severe and intractable depression. Evidence suggests ECT provokes an initial acute inflammatory response that subsequently decreases with repeated administration. However, relationships between inflammatory changes and clinical effects are unclear.
View Article and Find Full Text PDFAdult Neuropsychiatric Manifestation of Hartnup Disease With a Novel Variant: A Case Report.
Neurol Genet
December 2024
From the Department of Neurology (T.B., J.-J.R., F.T.B.), University Hospital Leipzig; Institute of Human Genetics (H.F., R.A.J.), University Hospital Leipzig; Department of Psychiatry (C.P., M.K.), University of Leipzig; Hospital for Psychiatry (M.K.), Psychotherapy und Psychosomatics, Klinikum Glauchau; Department of Pediatrics (S.B.), University Hospital Leipzig; and Centre for Rare Diseases (S.B., F.T.B.), University Hospital Leipzig, Germany.
Article Synopsis
- Inborn metabolic diseases in adults are often overlooked, particularly in routine diagnostics where suspicion is low.
- A young patient initially diagnosed with anxiety disorder was ultimately found to have Hartnup disease after a series of unsuccessful treatments and extensive testing, which included whole-exome sequencing.
- Following diagnosis, dietary changes and niacin supplementation led to significant improvements in the patient's condition, emphasizing the need for metabolic assessments in challenging neuropsychiatric cases.
MRI textural plasticity in limbic gray matter associated with clinical response to electroconvulsive therapy for psychosis.
Mol Psychiatry
September 2024
Department of Psychiatry, Hanyang University Hospital, Seoul, South Korea.
Article Synopsis
- Electroconvulsive therapy (ECT) is shown to help patients with treatment-resistant psychosis, yet the exact mechanisms of how it works are still not fully understood.
- This study used MRI texture analysis to investigate microstructural changes in limbic structures after ECT, demonstrating a correlation between these changes and improvement in symptoms, particularly in the left hippocampus and right amygdala.
- The research involved 36 patients undergoing ECT, 27 on medication alone, and 70 healthy controls, providing in vivo evidence supporting the idea that ECT induces neuroplastic changes that may be targeted for future treatments in psychosis.
The effects of treatment, clinical and demographic factors on recovery of orientation after ECT: A care network study.
J Affect Disord
January 2025
Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Australia; Black Dog Institute, Australia.
Background: Time to reorientation after electroconvulsive therapy (ECT) has been shown to predict retrograde amnesia and is a useful measure for monitoring patients over the acute treatment course. This study investigated the effects of treatment, clinical and demographic factors on the recovery of orientation after ECT.
Methods: Data from 555 ECT patients across two different clinical CARE Network sites were analysed.
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