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Zinc Finger SWIM-Type Containing 3 Reprograms Lipid Metabolism and Drives Breast Cancer Progression.
Discov Med
January 2025
Breast Surgery, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, 250001 Jinan, Shandong, China.
Background: Zinc finger proteins (ZNFs) have been proved to play important roles in driving the progression of breast cancer (BC), one of the most common cancers among women. This study aimed to investigate the involvement of zinc-finger SWIM domain-containing protein 3 () in promoting BC cell progression by regulating lipid metabolism.
Methods: Differential expression of in BC was confirmed by comparing its expression in normal human mammary epithelial cells and BC cells.
Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish.
Ecotoxicol Environ Saf
January 2025
Fisheries College, Huazhong Agricultural University, Wuhan 430070, China; Hubei Engineering Technology Research Center for Aquatic Animal Disease Control and Prevention, Wuhan 430070, China. Electronic address:
The toxicity of tris (2-butoxyethyl) phosphate (TBOEP) has been extensively investigated because of its prevalence in the environment. Nevertheless, the risk factors associated with maternal transmission are poorly understood. In this study, sexually mature female zebrafish were treated with TBOEP (0, 20, 100, and 500 μg/L) for 30 days and were mated with unexposed males.
View Article and Find Full Text PDFThe Role of the Parametric Thyroid Feedback Quantile Index in Cardiovascular Risk Evaluation Among Euthyroid Koreans.
J Clin Endocrinol Metab
January 2025
Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi-do, 18450, South Korea.
Context: Thyroid hormones play a crucial role in metabolic regulation and maintaining cardiovascular homeostasis. The Parametric Thyroid Feedback Quantile-based Index (PTFQI) assesses central thyroid hormone sensitivity by standardizing the inverse relationship between free thyroxine (T4) and thyroid-stimulating hormone (TSH).
Objective: To investigate the relationship between PTFQI and cardiovascular risk in the euthyroid Korean population.
The blind spots on chest computed tomography: what do we miss.
J Thorac Dis
December 2024
Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chest computed tomography (CT) is the most frequently performed imaging examination worldwide. Compared with chest radiography, chest CT greatly improves the detection rate and diagnostic accuracy of chest lesions because of the absence of overlapping structures and is the best imaging technique for the observation of chest lesions. However, there are still frequently missed diagnoses during the interpretation process, especially in certain areas or "blind spots", which may possibly be overlooked by radiologists.
View Article and Find Full Text PDF'PHACE' on the 'face'.
BMJ Case Rep
January 2025
Paediatric Department, SJOG Midland Public Hospital, Midland, Western Australia, Australia.
Infantile haemangiomas are a common presentation in infants within the first few months of life. The majority of haemangiomas are benign; however, large haemangiomas (≥5 cm), especially those involving the face, may indicate a more serious underlying neurocutaneous disorder known as PHACE (Posterior fossa malformations, Haemangioma, Arterial anomalies, Coarctation of the aorta/Cardiac defects and Eye abnormalities) syndrome. The authors report an unusual case of possible PHACE syndrome in a young male toddler with a large facial haemangioma.
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