Fractions of calf spleen extracts possessing the increased potency to inhibit the activity of DNase 1 were obtained by chromatography on columns with Sephadex G-200 and CM-cellulose. The fractions containing the most powerful inhibitor of DNase 1 increased the survival rate of sublethally irradiated mice and hamsters. A possible role of the DNase 1 inhibitor in cure effects is discussed.
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